Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Imaida K, Hagiwara A, Yoshino H, Tamano S, Sano M, Futakuchi M, Ogawa K, Asamoto M, Shirai T · 2000
View Original AbstractMelatonin supplementation protected against liver cancer development, highlighting why EMF's melatonin-suppressing effects matter for long-term health.
Plain English Summary
Researchers gave rats different doses of melatonin (a hormone that regulates sleep) and found it protected against early liver cancer development. This study was designed to understand why previous EMF exposure studies showed reduced liver tumors when EMF also reduced melatonin levels. The findings suggest that melatonin's protective effects may explain some unexpected results in EMF cancer research.
Why This Matters
This research provides crucial context for understanding EMF's complex effects on cancer development. The science demonstrates that melatonin, your body's natural sleep hormone, has protective effects against liver cancer precursors. What makes this particularly relevant is that EMF exposure consistently suppresses melatonin production in both laboratory studies and real-world measurements. The researchers found that even moderate melatonin supplementation reduced early cancer markers by measurable amounts. Put simply, this helps explain why some EMF studies show seemingly contradictory results. When EMF exposure simultaneously promotes cellular damage while suppressing melatonin (which would normally protect against that damage), the net cancer risk becomes difficult to predict from any single study.
Exposure Information
Specific exposure levels were not quantified in this study. Duration: 6 weeks
Study Details
The effects of different doses of melatonin (1, 5, 10 and 20 ppm in the drinking water) were analyzed in the same bioassay system employed for our previously reported EMF exposure studies.
Six-week-old male F344 rats were given a single dose of diethylnitrosamine (DEN, 200 mg/kg b.w., i.p...
only the first being elevated, while LH and testosterone were reduced. Although clear dose dependenc...
Comparison of the current results with the previously reported findings for EMF exposure experiments, suggests that increase in melatonin serum levels is a possible reason for the associated tendency for decreased preneoplastic hepatocyte foci development.
Show BibTeX
@article{k_2000_inhibitory_effects_of_low_2224,
author = {Imaida K and Hagiwara A and Yoshino H and Tamano S and Sano M and Futakuchi M and Ogawa K and Asamoto M and Shirai T},
title = {Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.},
year = {2000},
url = {https://pubmed.ncbi.nlm.nih.gov/10814886/},
}