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Pharmacological analysis of response latency in the hot plate test following whole-body static magnetic field-exposure in the snail Helix pomatia

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Hernádi L, László JF. · 2014

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A 30-minute static magnetic field exposure significantly changed pain response latency in snails, with effects linked to serotonin and opioid systems.

Plain English Summary

Summary written for general audiences

Researchers studied how a single, 30-minute, whole-body static magnetic field exposure at 147±3 mT affected pain response latency in the snail Helix pomatia, using the hot plate test. Compared to sham-exposure, the static magnetic field caused significant differences in response latency of up to 47.1% (p < 0.001). The study concluded that static magnetic field exposure mediates peripheral thermal nociceptive threshold by affecting the serotonin as well as the opioid system.

Why This Matters

Response latency was higher by 51.2% (p < 0.001) during the night compared to the day, and this day-night pattern also held for static magnetic field exposure, where night latency was higher by 28.6% (p < 0.001). Serotonin alone increased response latency by 55.7% (p < 0.001), while the serotonin antagonist tryptamine decreased it by 97.8% (p < 0.001). The opioid blocker naloxone decreased response latency by 52.5% (p < 0.001), but when static magnetic field exposure or serotonin was combined with naloxone, latency rose back above the control level.

Exposure Details

Magnetic Field
147±3 mT
Exposure Duration
30-min

Study Details

To study the effect of single, 30-min long, whole-body, homogeneous static magnetic field (SMF)-exposure of magnetic induction 147±3 mT on the response latency of the snail Helix pomatia.

The response was investigated using the hot plate test.

The effect caused by exposure to SMF was compared to sham-exposure and resulted in significant diffe...

This study provides evidence that SMF-exposure mediates peripheral thermal nociceptive threshold by affecting the serotonerg as well as the opioiderg system.

Cite This Study
Hernádi L, László JF. (2014). Pharmacological analysis of response latency in the hot plate test following whole-body static magnetic field-exposure in the snail Helix pomatia Int J Radiat Biol. 2014 Jul;90(7):547-553.
Show BibTeX
@article{l_2014_pharmacological_analysis_of_response_259,
  author = {Hernádi L and László JF.},
  title = {Pharmacological analysis of response latency in the hot plate test following whole-body static magnetic field-exposure in the snail Helix pomatia},
  year = {2014},
  doi = {10.3109/09553002.2014.899444},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2014.899444},
}
DOI: 10.3109/09553002.2014.899444

Cited By (6 papers)

Quick Questions About This Study

The study used the snail Helix pomatia, and pain response was investigated using the hot plate test.
Exposure to the static magnetic field resulted in significant differences of up to 47.1% (p < 0.001) compared to sham-exposure.
Response latency was higher by 51.2% (p < 0.001) during the night, and this pattern also held for static magnetic field exposure, where night latency was higher by 28.6% (p < 0.001).
Although naloxone alone decreased response latency by 52.5% (p < 0.001), combining it with static magnetic field exposure raised latency back above the control level by 116.9% (p < 0.001).
Researchers suggested that static magnetic field exposure mediates peripheral thermal nociceptive threshold by affecting the serotonin as well as the opioid system.