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Brain & Nervous System279 citations

Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons.

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Higuchi Y, Nashold BS Jr, Sluijter M, Cosman E, Pearlstein RD. · 2002

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Pulsed radiofrequency exposure of the dorsal root ganglion increased cFOS-immunoreactive neurons in the dorsal horn, while continuous radiofrequency did not.

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Summary written for general audiences

Researchers performed a left-sided hemilaminectomy in adult Sprague-Dawley rats to expose the C6 dorsal root ganglion. Rats received pulsed radiofrequency, continuous radiofrequency, or sham treatment with the electrode on the ganglion for 120 seconds. Pulsed radiofrequency significantly increased cFOS-immunoreactive neurons in the superficial dorsal horn laminae three hours after treatment, while continuous radiofrequency did not. The authors concluded that pulsed radiofrequency activates pain-processing neurons in the dorsal horn without tissue heating.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2 HzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2 Hz Duration: 120 seconds

Study Details

The present study was undertaken to identify spinal cord neurons activated by exposure of the dorsal ganglion to pulsed RF currents in rats.

Left-sided hemilaminectomy was performed in adult Sprague-Dawley rats to expose the C6 dorsal root g...

Treatment with pulsed RF but not continuous RF was associated with a significant increase in the num...

Exposure of the dorsal ganglion to pulsed RF currents activates pain-processing neurons in the dorsal horn. This effect is not mediated by tissue heating.

Cite This Study
Higuchi Y, Nashold BS Jr, Sluijter M, Cosman E, Pearlstein RD. (2002). Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons. Neurosurgery 50(4):850-856, 2002.
Show BibTeX
@article{y_2002_exposure_of_the_dorsal_2193,
  author = {Higuchi Y and Nashold BS Jr and Sluijter M and Cosman E and Pearlstein RD.},
  title = {Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons.},
  year = {2002},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/11904038/},
}
PubMed: 11904038

Cited By (279 papers)

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Quick Questions About This Study

The study aimed to identify spinal cord neurons activated by exposure of the dorsal root ganglion to pulsed radiofrequency currents in rats.
Rats received pulsed radiofrequency (20 ms of 500-kHz pulses at 2 Hz for 120 s to 38°C), continuous radiofrequency (continuous RF for 120 s to 38°C), or sham treatment (electrode contact only for 120 s).
Pulsed radiofrequency significantly increased cFOS-immunoreactive neurons in the superficial dorsal horn laminae three hours after treatment, while continuous radiofrequency did not.
The authors concluded that pulsed radiofrequency activates pain-processing neurons in the dorsal horn and that this effect is not mediated by tissue heating.
Adult Sprague-Dawley rats underwent left-sided hemilaminectomy to expose the C6 dorsal root ganglion.