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Transient and steady-state magnetic fields induce increased fluorodeoxyglucose uptake in the rat hindbrain.

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Frilot C 2nd, Carrubba S, Marino AA. · 2011

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Rat hindbrain glucose uptake increased when a magnetic field was applied orthogonally to the sagittal plane, but not when the field angle varied randomly.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to a 2.5-G, 60-Hz magnetic field and used positron emission tomography with fluorodeoxyglucose to identify brain regions where glucose uptake changed. Increased glucose utilization occurred in hindbrain voxels when the field was applied orthogonally to the sagittal plane, but not when the angle between the field and the sagittal plane varied randomly. Distinct activation effects were observed in response to transient and steady-state magnetic stimuli.

Why This Matters

The study aimed to extend earlier findings and to test whether electromagnetic field transduction depended on the direction of the field. Brain scans taken with and without field exposure from the same animal were subtracted and averaged, and statistical t values for each brain voxel were compared against a critical t value to identify field-activated voxels. The researchers suggested that the direction-dependence of glucose utilization indicated that signal transduction was mediated by a force detector and that the process occurred in the hindbrain.

Exposure Details

Magnetic Field
25 mT
Source/Device
2.5‐G, 60‐Hz
Exposure Duration
45 min

Exposure Context

This study used 25 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 25 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 125 times the FCC limit

Study Details

The authors wanted to extend results from previous studies and to study whether electromagnetic field transduction was dependent on the direction of the field, and whether the previously reported electromagnetic field effects on fluorodeoxyglucose (FDG) uptake (see Frilot 2nd et al. 2009) actually were related to those field effects.

Rats were exposed to a 2.5‐G, 60‐Hz magnetic field and the neuroanatomical region of glucose activat...

Increased glucose utilization occurred in hindbrain voxels when the field was applied orthogonally to the sagittal plane, but not when the angle between the field and the sagittal plane varied randomly. Distinct FDG activation effects were observed in response to transient (both onset and offset) and steady‐state magnetic stimuli. Observations of increased glucose utilization induced by magnetic stimuli and its dependence on the direction of the field suggested that signal transduction was mediated by a force detector and that the process and/or early posttransduction processing occurred in the hindbrain.

Cite This Study
Frilot C 2nd, Carrubba S, Marino AA. (2011). Transient and steady-state magnetic fields induce increased fluorodeoxyglucose uptake in the rat hindbrain. Synapse. 65(7):617-623, 2011.
Show BibTeX
@article{2nd_2011_transient_and_steadystate_magnetic_250,
  author = {Frilot C 2nd and Carrubba S and Marino AA.},
  title = {Transient and steady-state magnetic fields induce increased fluorodeoxyglucose uptake in the rat hindbrain.},
  year = {2011},
  doi = {10.1002/syn.20882},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.20882},
}
DOI: 10.1002/syn.20882

Cited By (7 papers)

Quick Questions About This Study

Rats were exposed to a 2.5-G, 60-Hz magnetic field.
Increased glucose utilization occurred when the field was applied orthogonally to the sagittal plane, but not when the field angle varied randomly.
Increased glucose utilization occurred in hindbrain voxels when the field was applied orthogonally to the sagittal plane.
Distinct activation effects were observed in response to transient stimuli, including both onset and offset, as well as steady-state magnetic stimuli.
The researchers suggested that signal transduction was mediated by a force detector and that the process and/or early posttransduction processing occurred in the hindbrain.