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Brain & Nervous System

Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma

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Del Giudice E, Facchinetti F, Nofrate V, Boccaccio P, Minelli T, Dam M, Leon A, Moschini G. · 2007

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Overnight exposure to a 3.1 mT 50 Hz low-frequency electromagnetic field significantly increased amyloid-beta secretion in cultured human neuroglioma cells.

Plain English Summary

Summary written for general audiences

Researchers tested whether low-frequency electromagnetic field exposure could affect amyloidogenic processes in cultured cells. They exposed H4 neuroglioma cells that stably overexpress human mutant amyloid precursor protein to a 3.1 mT 50 Hz field. Overnight exposure significantly increased secretion of amyloid-beta peptide, including the isoform Aβ 1–42, without affecting cell survival.

Why This Matters

The researchers described their results as showing for the first time that exposure to LF-EMF stimulates Aβ secretion in vitro. The authors suggested this alluded to a potential link between LF-EMF exposure and APP processing in the brain.

Exposure Details

Magnetic Field
3.1 mT
Source/Device
50 Hz

Exposure Context

This study used 3.1 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 3.1 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 16 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

We here tested the hypothesis that the exposure to LF-EMF may affect amyloidogenic processes.

We examined the effect of exposure to 3.1 mT 50 Hz LF-EMF on Aβ secretion in H4 neuroglioma cells st...

We found that overnight exposure to LF-EMF induces a significant increase of amyloid-beta peptide (A...

These findings show for the first time that exposure to LF-EMF stimulates Aβ secretion in vitro, thus alluding to a potential link between LF-EMF exposure and APP processing in the brain.

Cite This Study
Del Giudice E, Facchinetti F, Nofrate V, Boccaccio P, Minelli T, Dam M, Leon A, Moschini G. (2007). Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma Neurosci Lett. 418(1):9-12, 2007.
Show BibTeX
@article{e_2007_fifty_hertz_electromagnetic_field_240,
  author = {Del Giudice E and Facchinetti F and Nofrate V and Boccaccio P and Minelli T and Dam M and Leon A and Moschini G.},
  title = {Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma},
  year = {2007},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394007002480},
}

Quick Questions About This Study

The study used H4 neuroglioma cells that stably overexpress human mutant amyloid precursor protein.
Cells were exposed to a 3.1 mT 50 Hz low-frequency electromagnetic field overnight.
The exposure did not affect cell survival.
The authors said the findings alluded to a potential link between LF-EMF exposure and APP processing in the brain.