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Deleterious impacts of a 900MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male rats

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Şahin A, Aslan A, Baş O, İkinci A, Özyılmaz C, Fikret Sönmez O, Çolakoğlu S, Odacı E. · 2015

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Rats exposed to 900 MHz EMF for 1 hour daily over 30 days had significantly fewer pyramidal neurons in the cornu ammonis and showed abnormal cell morphology.

Plain English Summary

Summary written for general audiences

The study consisted of control, sham-exposed, and EMF-exposed groups with six rats in each. The EMF-exposed group received 900 MHz EMF for 1 hour per day for 30 days while the sham group was placed in the same jar without exposure. Stereological analysis revealed a significantly lower total number of pyramidal neurons in the cornu ammonis of EMF-exposed rats compared to both control and sham groups, and histopathology showed abnormal cells with dark cytoplasm and shrunken morphology.

Why This Matters

The researchers chose 8-week-old rats because this age corresponds to the preadolescent period in humans. The largest lateral ventricles were observed in the EMF-exposed group compared to the other groups. Neuron numbers were estimated using the optical dissector technique on Cresyl violet stained sections.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900-MHz Duration: 1 h/day for 30 days

Study Details

To study the deleterious impacts of a 900-MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male rats

We examined 8-week-old rats because this age of the rats is comparable with the preadolescent period...

Histopathological observation showed abundant cells with abnormal, black or dark blue cytoplasm and ...

In conclusion, our results suggest that pyramidal neuron loss and histopathological changes in the cornu ammonis of 8-week-old male rats may be due to the 900-MHz EMF exposure.

Cite This Study
Şahin A, Aslan A, Baş O, İkinci A, Özyılmaz C, Fikret Sönmez O, Çolakoğlu S, Odacı E. (2015). Deleterious impacts of a 900MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male rats Brain Res. 2015 Jul 31. pii: S0006-8993(15)00586-7. doi: 10.1016/j.brainres.2015.07.042.
Show BibTeX
@article{a_2015_deleterious_impacts_of_a_1528,
  author = {Şahin A and Aslan A and Baş O and İkinci A and Özyılmaz C and Fikret Sönmez O and Çolakoğlu S and Odacı E. },
  title = {Deleterious impacts of a 900MHz electromagnetic field on hippocampal pyramidal neurons of 8-week-old Sprague Dawley male rats},
  year = {2015},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0006899315005867},
}

Quick Questions About This Study

The EMF-exposed rats were exposed to 900 MHz EMF for 1 hour per day for 30 days in an EMF jar.
The study consisted of control, sham-exposed, and EMF-exposed groups with six rats in each.
Histopathology showed abundant cells with abnormal dark cytoplasm and shrunken morphology, and the lateral ventricles were largest in the EMF-exposed group.
Stereological analysis showed the total number of pyramidal neurons in the cornu ammonis was significantly lower in EMF-exposed rats compared to both control and sham groups.
The researchers concluded that pyramidal neuron loss and histopathological changes in the cornu ammonis of 8-week-old male rats may be due to 900-MHz EMF exposure.