8-Oxo-7, 8-dihydro-2'-deoxyguanosine as a biomarker of DNA damage by mobile phone radiation.
Khalil AM, Gagaa MH, Alshamali AM. · 2012
View Original AbstractCell phone radiation at legal SAR limits causes measurable DNA damage in real-time, with peak damage occurring within one hour of exposure.
Plain English Summary
Researchers exposed rats to cell phone radiation at 1800 MHz for 2 hours and measured a specific marker of DNA damage (8-oxodG) in their urine. They found significant increases in DNA damage markers throughout most of the exposure period, with peak damage occurring 1 hour after exposure began. This suggests that cell phone radiation can cause oxidative damage to DNA, which is a key mechanism linked to cancer development.
Why This Matters
This study provides direct biological evidence that cell phone radiation causes DNA damage through oxidative stress. The exposure level used (1.0 W/kg SAR) is at the legal limit for cell phones in many countries, making these findings highly relevant to everyday phone use. What makes this research particularly compelling is the real-time measurement of DNA damage markers in urine, showing that cellular repair mechanisms are actively working to fix radiation-induced damage. The peak damage at 1 hour followed by repair activity demonstrates that our cells are under constant stress when exposed to RF radiation. This adds to the growing body of evidence showing that current safety standards may not adequately protect against the biological effects of wireless technology.
Exposure Details
- SAR
- 1 W/kg
- Source/Device
- 1800 MHz
- Exposure Duration
- RFR for 2 h and 4-h period at 0.5, 1.0, 2.0 and 4.0 h
Exposure Context
This study used 1 W/kg for SAR (device absorption):
- 2.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We examined the effect of exposure to mobile phone 1800 MHz radio frequency radiation (RFR) upon the urinary excretion of 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG), one major form of oxidative DNA damage, in adult male Sprague-Dawley rats
Twenty-four rats were used in three independent experiments (RFR exposed and control, 12 rats, each)...
With the exception of the urine collected in the last half an hour of exposure, significant elevatio...
Show BibTeX
@article{am_2012_8oxo7_8dihydro2deoxyguanosine_as_a_541,
author = {Khalil AM and Gagaa MH and Alshamali AM.},
title = {8-Oxo-7, 8-dihydro-2'-deoxyguanosine as a biomarker of DNA damage by mobile phone radiation.},
year = {2012},
doi = {10.1177/0960327111433184},
url = {https://journals.sagepub.com/doi/abs/10.1177/0960327111433184},
}