Effects of short term and long term Extremely Low Frequency Magnetic Field on depressive disorder in mice: Involvement of nitric oxide pathway
Ansari AM, Farzampour S, Sadr A, Shekarchi B, Majidzadeh-A K. · 2016
View Original AbstractLong-term ELF magnetic field exposure significantly reduced immobility time in mice, suggesting an effect on depressive behavior, while short-term exposure had no significant effect.
Plain English Summary
Researchers exposed male adult NMRI mice to an extremely low frequency magnetic field at 0.5 mT and 50 Hz, either as a single 2-hour session or for 2 hours a day over 2 weeks. Depressive-like behavior was measured using the Forced Swimming Test, which records immobility time. Long-term exposure significantly reduced immobility time, while short-term exposure did not alter it.
Why This Matters
The study used the Forced Swimming Test, in which immobility time is taken as an indicator of depressive-like behavior in mice. Locomotor activity was checked with an open-field test, and locomotion did not differ among any of the experimental groups. The researchers also tested the drug NΩ-nitro-l-arginine methyl ester at 30 mg/kg, which was used to produce an antidepressant-like effect. Short-term exposure reversed that antidepressant-like effect at a statistically significant level. The authors concluded that long-term exposure could alter depressive disorder in mice, whereas short-term exposure had no significant effect.
Exposure Details
- Magnetic Field
- 0.5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- single 2 h and 2 weeks 2 h a day
Exposure Context
This study used 0.5 mT for magnetic fields:
- 25Kx above the Building Biology guideline of 0.2 mG
- 5Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In the current study, we aimed to assess the possible effect(s) of ELF MF exposure on mice Forced Swimming Test (FST) and evaluate the probable role of the increased level of nitric oxide in the observed behavior.
Male adult mice NMRI were recruited to investigate the short term and long term ELF MF exposure (0.5...
According to the results, short term exposure did not alter the immobility time, whereas long term e...
It has been concluded that long term exposure could alter the depressive disorder in mice, whereas short term exposure has no significant effect. Also, reversing the anti-depressant activity of L-NAME indicates a probable increase in the brain nitric oxide.
Show BibTeX
@article{am_2016_effects_of_short_term_320,
author = {Ansari AM and Farzampour S and Sadr A and Shekarchi B and Majidzadeh-A K.},
title = {Effects of short term and long term Extremely Low Frequency Magnetic Field on depressive disorder in mice: Involvement of nitric oxide pathway},
year = {2016},
url = {https://www.sciencedirect.com/science/article/abs/pii/S002432051530148X},
}