Experimental evidence for involvement of nitric oxide in low frequency magnetic field induced obsessive compulsive disorder-like behavior.
Salunke BP, Umathe SN, Chavan JG · 2014
View Original AbstractExposing mice to a low-frequency magnetic field raised nitric oxide levels in the brain and produced obsessive-compulsive-like behavior, while dopamine and serotonin levels remained unaffected.
Plain English Summary
Researchers exposed Swiss albino mice to an extremely low frequency magnetic field (50 Hz, 10 G) for 8 hours per day for up to 120 days to study obsessive-compulsive disorder-like behavior. OCD-like behavior was measured using the marble burying behavior test, and the results showed that the magnetic field induced time-dependent marble burying behavior on each exposure day tested. A nitric oxide precursor worsened the OCD-like behavior, while nitric oxide synthase inhibitors reduced it, with corresponding changes in nitric oxide levels.
Why This Matters
The study used the marble burying behavior test as a proxy measure for OCD-like behavior in mice. Exposures were conducted using Helmholtz coils at 50 Hz and 10 G, with animals assessed at multiple time points across up to 120 days. The researchers investigated whether dopamine, serotonin, or nitric oxide were involved in the observed behavior changes. Because the OCD-like behavior was associated with higher nitric oxide levels but no significant change in serotonin and dopamine, the researchers then tested nitric oxide modulators. Groups of mice were concurrently treated with the nitric oxide precursor l-ARG at 400 mg/kg, or the nitric oxide synthase inhibitors l-NAME at 15.0 mg/kg or 7-NI at 10.0 mg/kg.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 8 hours/day for 7, 30, 60, 90 or 120 days
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
the present study was carried out to understand the involvement of dopamine, serotonin and NO in ELF MF induced OCD-like behavior.
Swiss albino mice were exposed to ELF MF (50 Hz, 10 G) for 8 h/day for 7, 30, 60, 90 and 120 days by...
These treatments revealed that NO precursor exacerbated and NOS inhibitors attenuated ELF MF induced...
Show BibTeX
@article{bp_2014_experimental_evidence_for_involvement_294,
author = {Salunke BP and Umathe SN and Chavan JG},
title = {Experimental evidence for involvement of nitric oxide in low frequency magnetic field induced obsessive compulsive disorder-like behavior.},
year = {2014},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0091305714001154},
}