Analysis of DNA fragmentation in mouse embryos exposed to an extremely low-frequency electromagnetic field
Authors not listed · 2011
Mice exposed to a 50-Hz, 0.5 mT field for two weeks had fewer blastocysts and more DNA fragmentation in embryos.
Plain English Summary
Researchers exposed female NMRI mice to a 50-Hz, 0.5 mT electromagnetic field for four hours per day, six days a week over two weeks. After eight days of exposure, the mice were superovulated with hormone injections, mated overnight, and blastocysts were flushed from the uterus at about four days post-mating. The exposed group had significantly fewer blastocysts than controls. DNA fragmentation in blastocyst cells was significantly higher in the exposed group (10.53% vs 7.14%). The numbers of blastomeres and pregnant mice did not differ significantly between groups.
Why This Matters
The control group was left unexposed while the EMF group received the field. The researchers compared outcomes using SPSS with Chi-square, Student's t-test, and Mann-Whitney U-test, with significance set at P < 0.05. The authors concluded that preimplantation EMF exposure may harm female mouse fertility and embryo development by reducing blastocyst numbers and raising DNA fragmentation.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{analysis_of_dna_fragmentation_in_mouse_embryos_exposed_to_an_extremely_low_frequency_electromagnetic_field_ce2098,
author = {Unknown},
title = {Analysis of DNA fragmentation in mouse embryos exposed to an extremely low-frequency electromagnetic field},
year = {2011},
doi = {10.3109/15368378.2011.589556},
}