Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain.
Janać B, Tovilović G, Tomić M, Prolić Z, Radenović L. · 2009
View Original AbstractIn adult rats, continuous exposure to a 50 Hz, 0.5 mT magnetic field altered serotonin receptor affinity and density in the prefrontal cortex, while dopamine receptors in the striatum were unaffected.
Plain English Summary
Researchers exposed adult Wistar rats continuously to an extremely low frequency magnetic field (50 Hz, 0.5 mT) for 1, 3, and 7 days. The study examined serotonin 5-HT(2A) receptors in the prefrontal cortex and dopamine D(1) and D(2) receptors in the striatum, considering their involvement in motor behavior regulation. Serotonin 5-HT(2A) receptor affinity decreased and density increased in the prefrontal cortex, with the affinity effect being most prominent after 7 days of exposure. Dopamine D(1) and D(2) receptors in the striatum showed no significant effect on either affinity or density.
Why This Matters
Receptor binding properties were measured using in vitro radioligand receptor binding assays. The change in serotonin receptor affinity was duration-dependent, meaning the effect varied depending on whether rats were exposed for 1, 3, or 7 days. The researchers concluded that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, and that the intensity of these changes depends on exposure duration. In contrast, the dopamine system in the striatum did not show significant changes in receptor affinity or density under the same exposure conditions.
Exposure Details
- Magnetic Field
- 0.5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 1, 3, and 7 days
Exposure Context
This study used 0.5 mT for magnetic fields:
- 25Kx above the Building Biology guideline of 0.2 mG
- 5Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
the purpose of this study was to examine MF-induced changes in the activity of serotonin 5-HT(2A) receptors in the prefrontal cortex, as well as dopamine D(1) and D(2) receptors in the striatum of adult Wistar rats, considering their involvement in motor behavior regulation.
Experimental animals were continuously exposed to extremely low frequency MF (ELF-MF, 50 Hz, 0.5 mT)...
It was shown that the affinity of serotonin 5-HT(2A) receptors decreased and their density increased...
We can conclude that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, whereby intensity of these changes depends on ELF-MF exposure duration.
Show BibTeX
@article{b_2009_effect_of_continuous_exposure_263,
author = {Janać B and Tovilović G and Tomić M and Prolić Z and Radenović L. },
title = {Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain.},
year = {2009},
url = {https://www.researchgate.net/profile/Branka-Petkovic-former-Janac/publication/51439500_Effect_of_continuous_exposure_to_alternating_magnetic_field_50_Hz_05_mT_on_serotonin_and_dopamine_receptors_activity_in_rat_brain/links/00b7d51c2d116b2778000000/Effect-of-continuous-exposure-to-alternating-magnetic-field-50-Hz-05-mT-on-serotonin-and-dopamine-receptors-activity-in-rat-brain.pdf},
}