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Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice

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Cuccurazzu B, Leone L, Podda MV, Piacentini R, Riccardi E, Ripoli C, Azzena GB, Grassi C. · 2010

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50 Hz magnetic fields enhanced brain cell growth and memory in mice, but at levels 1000 times higher than typical household exposure.

Plain English Summary

Summary written for general audiences

Researchers exposed mice to 50 Hz electromagnetic fields (power line frequency) for up to seven hours daily over one week. The exposure significantly increased new brain cell growth in the hippocampus, the brain region responsible for memory formation, suggesting certain EMF exposures may enhance rather than harm brain function.

Why This Matters

This study presents a fascinating counterpoint to the typical narrative around EMF health effects. While most research focuses on potential harms from electromagnetic field exposure, these findings demonstrate that 50 Hz magnetic fields at 1 milliTesla can actually enhance neurogenesis and improve brain function in mice. The exposure level used here is significantly higher than what you'd encounter from typical household appliances or power lines, which typically generate fields in the microTesla range. What makes this research particularly intriguing is that it shows not just cellular changes, but functional improvements in memory formation. However, we should interpret these results cautiously. The science demonstrates that EMF effects are highly dependent on frequency, intensity, duration, and biological context. Just because one specific exposure pattern showed benefits in mice doesn't mean all EMF exposures are beneficial, nor does it negate the substantial body of research showing potential risks from other types of electromagnetic radiation, particularly radiofrequency fields from wireless devices.

Exposure Details

Magnetic Field
1 mG
Source/Device
50 Hz
Exposure Duration
1 to 7 h/day for 7 days

Exposure Context

This study used 1 mG for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 1 mGExtreme Concern5 mGFCC Limit2,000 mGEffects observed in the Severe Concern range (Building Biology)FCC limit is 2,000x higher than this exposure level

Study Details

The aim of the present study was to determine whether 50-Hz/1 mT ELFEF stimulation also affects adult hippocampal neurogenesis in vivo, and if so, to identify the molecular mechanisms underlying this action and its functional impact on synaptic plasticity.

ELFEF exposure (1 to 7 h/day for 7 days) significantly enhanced neurogenesis in the dentate gyrus (...

Our findings show that ELFEF exposure can be an effective tool for increasing in vivo neurogenesis, and they could lead to the development of novel therapeutic approaches in regenerative medicine.

Cite This Study
Cuccurazzu B, Leone L, Podda MV, Piacentini R, Riccardi E, Ripoli C, Azzena GB, Grassi C. (2010). Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice Exp Neurol. 226(1):173-182, 2010.
Show BibTeX
@article{b_2010_exposure_to_extremely_lowfrequency_236,
  author = {Cuccurazzu B and Leone L and Podda MV and Piacentini R and Riccardi E and Ripoli C and Azzena GB and Grassi C.},
  title = {Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice},
  year = {2010},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0014488610003213},
}

Quick Questions About This Study

Researchers exposed mice to 50 Hz electromagnetic fields (power line frequency) for up to seven hours daily over one week. The exposure significantly increased new brain cell growth in the hippocampus, the brain region responsible for memory formation, suggesting certain EMF exposures may enhance rather than harm brain function.