Cancer & Tumors781 citations
Biology (Basel) 11(2):323, 2022.(AS, AE, CC, IX)
Bioeffects Seen
Authors not listed · 2022
Insufficient information to determine key finding.
Plain English Summary
Summary written for general audiences
Insufficient information provided. Only a citation (Biology (Basel) 11(2):323, 2022) and organism type (review) were supplied, with no title, abstract, or content details. Cannot determine if this is an EMF health effects study or summarize findings without actual study information.
Why This Matters
A complete record requires at minimum the study title and abstract to assess relevance to EMF health effects research and generate accurate summaries.
Exposure Information
Specific exposure levels were not quantified in this study.
Cite This Study
Unknown (2022). Biology (Basel) 11(2):323, 2022.(AS, AE, CC, IX).
Show BibTeX
@article{biology_basel_112323_2022as_ae_cc_ix_ce4398,
author = {Unknown},
title = {Biology (Basel) 11(2):323, 2022.(AS, AE, CC, IX)},
year = {2022},
doi = {10.1186/s12943-023-01744-8},
}Quick Questions About This Study
Cancer cells alter the structural framework around them to create a protective barrier. This remodeled matrix helps tumors resist treatments, avoid immune system detection, and provides pathways for metastasis to distant organs.
ECM normalization involves restoring the altered extracellular matrix back to its healthy state. This therapeutic approach aims to remove the protective barriers that cancer creates, making tumors more vulnerable to treatments and immune responses.
Yes, the study suggests that normalizing the remodeled matrix could enhance immunotherapy success. The altered ECM creates an immune-suppressive environment, so restoring normal matrix structure may help immune cells better recognize and attack cancer.
Matrix remodeling influences multiple cancer processes including cell proliferation, resistance to cell death, metastasis, blood vessel formation, lymphatic vessel development, and immune system evasion. These changes collectively support tumor progression and treatment resistance.
Cancer cells control matrix remodeling through abnormal activation of signaling pathways, interactions between matrix components and cell surface receptors, and mechanical forces. These mechanisms allow tumors to systematically reshape their surrounding environment.