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Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention.

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De Luca C, Chung Sheun Thai J, Raskovic D, Cesareo E, Caccamo D, Trukhanov A, Korkina L. · 2014

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Researchers found distinct metabolic changes and genetic variants linked to electromagnetic hypersensitivity.

Plain English Summary

Summary written for general audiences

The study tested a panel of 12 metabolic blood redox-related parameters and selected drug-metabolizing-enzyme gene polymorphisms in 153 EHS, 147 MCS, and 132 control Italians. They found milder pro-oxidant and proinflammatory changes in the electromagnetic hypersensitivity group, including an increased plasma coenzyme-Q10 oxidation ratio. Genetic analysis showed altered distribution of CYP2C19 variants and a 9.7-fold higher risk of electromagnetic hypersensitivity for a combined GSTT1 and GSTM1 null haplotype.

Why This Matters

The researchers also reported severe depletion of erythrocyte membrane polyunsaturated fatty acids and an increased omega-6 to omega-3 ratio in multiple chemical sensitivity, but not in electromagnetic hypersensitivity. They proposed that the blood metabolic and genetic biomarker panel could serve as a suitable diagnostic tool for SRI. The study confirmed altered glutathione, glutathione peroxidase, glutathione S-transferase, and catalase activities in multiple chemical sensitivity.

Study Details

The purpose of this study is to observe Metabolic and Genetic Screening of Electromagnetic Hypersensitive Subjects as a Feasible Tool for Diagnostics and Intervention

we tested a panel of 12 metabolic blood redox-related parameters and of selected drug-metabolizing-e...

We first described comparable-though milder-metabolic pro-oxidant/proinflammatory alterations in EHS...

Altogether, results on MCS and EHS strengthen our proposal to adopt this blood metabolic/genetic biomarkers' panel as suitable diagnostic tool for SRI.

Cite This Study
De Luca C, Chung Sheun Thai J, Raskovic D, Cesareo E, Caccamo D, Trukhanov A, Korkina L. (2014). Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention. Mediators Inflamm. 2014;2014:924184. doi: 10.1155/2014/924184. Epub 2014 Apr 9.
Show BibTeX
@article{c_2014_metabolic_and_genetic_screening_1628,
  author = {De Luca C and Chung Sheun Thai J and Raskovic D and Cesareo E and Caccamo D and Trukhanov A and Korkina L.},
  title = {Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention.},
  year = {2014},
  
  url = {https://www.hindawi.com/journals/mi/2014/924184/},
}

Quick Questions About This Study

They found milder pro-oxidant and proinflammatory alterations, including an increased plasma coenzyme-Q10 oxidation ratio.
The CYP2C19*1/*2 SNP variants showed altered distribution, and a combined null GSTT1 and GSTM1 haplotype conferred a 9.7-fold increased risk.
Severe depletion of erythrocyte membrane polyunsaturated fatty acids with an increased omega-6 to omega-3 ratio was confirmed in multiple chemical sensitivity but not in electromagnetic hypersensitivity.
They proposed adopting the blood metabolic and genetic biomarker panel as a suitable diagnostic tool for SRI.
The study included 153 EHS, 147 MCS, and 132 control Italians.