Effect of Terahertz Waves on the Structure of the Aβ42 Monomer, Dimer, and Protofibril: Insights from Molecular Dynamics Simulations
Chen C, Yan Z-S Ma Y-Q, Ding H-M · 2023
Terahertz waves at 42.55 THz enhance interactions in Aβ42 monomers and dimers, increase β-structure content, enhance dimer binding energy, and mildly stabilize tetrameric protofibrils.
Plain English Summary
Researchers used all-atom molecular dynamics simulations to investigate how terahertz waves affect the structure of Aβ42 monomer, dimer, and tetramer. Terahertz waves at 42.55 THz enhanced intramolecular interactions in the monomer and intermolecular interactions in the dimer by resonating with specific molecular vibrations. This increased β-structure content in the monomer and significantly enhanced binding energy in the dimer. Terahertz waves also mildly stabilized tetrameric protofibrils by enhancing interactions among peripheral peptides.
Why This Matters
The researchers also examined how different terahertz frequencies affect Aβ42 structure. The study suggests these findings may help understand potential risks of electromagnetic field radiation on Aβ42 peptides.
Show BibTeX
@article{chen_c_yan_z_s_ma_y_q_ding_h_m_ce3181,
author = {Chen C and Yan Z-S Ma Y-Q and Ding H-M},
title = {Effect of Terahertz Waves on the Structure of the Aβ42 Monomer, Dimer, and Protofibril: Insights from Molecular Dynamics Simulations},
year = {2023},
}