Combined effect of pulsed electromagnetic field and sound wave on In vitro and In vivo neural differentiation of human mesenchymal stem cells
Choi Y-K, Urnukhsaikhan E, Yoon H-H, Seo Y-K, Cho H, Jeong J-S, Kim S-C, Jung- Keug Park J-K · 2017
Combined PEMF and sound wave exposure accelerated neural-related genes in human mesenchymal stem cells more than either stimulus alone and reduced brain infarction in mice.
Plain English Summary
Researchers investigated the synergistic effect of pulsed electromagnetic fields and sound waves on neural differentiation of human bone marrow mesenchymal stem cells in vitro and in vivo. Combined exposure accelerated neural-related genes more than individual exposure to either stimulus. The combined wave up-regulated neural and synaptic proteins in 3-D culture through ERK phosphorylation. In a mouse stroke model, combined wave exposure reduced infarction volume and improved behavioral activity.
Why This Matters
The authors concluded that combined biophysical wave stimuli can enhance and possibly affect MSC differentiation into neural cells. They highlighted the potential of combined wave therapy for neurogenic effects and new neural cell therapy approaches.
Show BibTeX
@article{choi_y_k_urnukhsaikhan_e_yoon_h_h_seo_y_k_cho_h_jeong_j_s_kim_s_c_jung_keug_park_j_k_ce4322,
author = {Choi Y-K and Urnukhsaikhan E and Yoon H-H and Seo Y-K and Cho H and Jeong J-S and Kim S-C and Jung- Keug Park J-K},
title = {Combined effect of pulsed electromagnetic field and sound wave on In vitro and In vivo neural differentiation of human mesenchymal stem cells},
year = {2017},
}