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Circadian gene expression and extremely low-frequency magnetic fields: An in vitro study

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Manzella N et al · 2015

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An ELF magnetic field at 0.1 mT and 50 Hz entrained expression of circadian clock genes BMAL1, PER2, PER3, CRY1, and CRY2 in human fibroblasts.

Plain English Summary

Summary written for general audiences

Researchers investigated effects of ELF magnetic fields on circadian clock genes in a human fibroblast cell line. An ELF-MF exposure at 0.1 mT and 50 Hz entrained expression of clock genes BMAL1, PER2, PER3, CRY1, and CRY2. ELF-MF treatment also altered circadian clock gene expression previously entrained by serum shock stimulation.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Manzella N et al (2015). Circadian gene expression and extremely low-frequency magnetic fields: An in vitro study.
Show BibTeX
@article{manzella_n_et_al_march_2015_circadian_gene_expression_and_extremely_low_frequency_magnetic_fields_an_in_vitro_study_bioelectromagnetics_ce2039,
  author = {Manzella N et al},
  title = {Circadian gene expression and extremely low-frequency magnetic fields: An in vitro study},
  year = {2015},
  doi = {10.1002/bem.21915},
  
}
DOI: 10.1002/bem.21915PubMed: 25808738

Quick Questions About This Study

The study used an ELF-MF exposure at 0.1 mT and 50 Hz.
The exposure entrained expression of BMAL1, PER2, PER3, CRY1, and CRY2.
ELF-MF treatment induced an alteration in circadian clock gene expression previously entrained by serum shock stimulation.
The study used a human fibroblast cell line.