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Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model

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Costantini E, Aielli L, Serra F, De Dominicis L, Falasca K, Di Giovanni P, Reale M · 2022

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RF-EMF exposure showed potential as a non-invasive therapeutic approach to accelerate wound healing by promoting cell migration and modulating expression of genes critical to the healing process.

Plain English Summary

Summary written for general audiences

This 2022 review examined how radiofrequency electromagnetic field (RF-EMF) exposure affects wound healing processes in vitro, specifically evaluating effects on keratinocyte migration and expression of healing-related genes including matrix metalloproteinases and cytokines. The study found that RF-EMF treatment promoted keratinocyte migration and regulated genes involved in the inflammatory and proliferative phases of wound healing.

Why This Matters

Wound healing involves coordinated cellular and molecular events across multiple phases, and electromagnetic field therapies have existing clinical applications in musculoskeletal and pain management. This review synthesizes evidence on RF-EMF's mechanistic effects on wound healing at the cellular level, contributing to understanding of potential therapeutic applications in tissue repair.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Costantini E, Aielli L, Serra F, De Dominicis L, Falasca K, Di Giovanni P, Reale M (2022). Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model.
Show BibTeX
@article{costantini_e_aielli_l_serra_f_de_dominicis_l_falasca_k_di_giovanni_p_reale_m_ce2346,
  author = {Costantini E and Aielli L and Serra F and De Dominicis L and Falasca K and Di Giovanni P and Reale M},
  title = {Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model},
  year = {2022},
  doi = {10.1016/S0140-6736(22)01846-3},
  
}
DOI: 10.1016/S0140-6736(22)01846-3PubMed: 35216321

Quick Questions About This Study

The surgical preparedness index included 11 indicators on facilities and consumables, two on staffing, two on prioritisation, and eight on systems. These were selected from 103 candidate indicators by 69 clinicians from 32 countries through a four-stage consensus process.
74.6% of hospitals (1,217 out of 1,632) failed to maintain their expected surgical volume during COVID-19. The impact varied by income level: 51.4% of affected hospitals were in high-income countries, 44.2% in middle-income, and 4.4% in low-income countries.
The mean surgical preparedness index score was 84.5 out of 115 points globally. High-income countries averaged 88.5 points, middle-income countries 81.8 points, and low-income countries scored lowest at 66.8 points, showing significant preparedness disparities.
Each 10-point increase in surgical preparedness score corresponded to a 3.6% increase in maintained surgical volume during COVID-19. This relationship held consistent across high-income (4.8%), middle-income (2.8%), and low-income (3.8%) country settings.
The study involved 4,714 clinicians measuring surgical preparedness across 1,632 hospitals in 119 countries. Nearly half (45.6%) of participating hospitals were located in middle-income or low-income countries, providing global representation of surgical system capacity.