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Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model

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Costantini E, Aielli L, Serra F, De Dominicis L, Falasca K, Di Giovanni P, Reale M · 2022

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RF-EMF exposure demonstrated potential as a therapeutic approach to enhance wound healing through effects on cell migration and regulation of healing-related gene expression in cultured keratinocytes.

Plain English Summary

Summary written for general audiences

This 2022 in vitro study investigated how radiofrequency electromagnetic field (RF-EMF) exposure affects wound healing by examining keratinocyte migration and expression of genes involved in the healing process. The researchers found that RF-EMF treatment promoted keratinocyte migration and regulated expression of matrix metalloproteinases, their inhibitors, and inflammatory cytokines in ways that appeared to support wound healing.

Why This Matters

Wound healing involves coordinated phases of inflammation and tissue remodeling mediated by cytokines and matrix metalloproteinases. This study used an in vitro model to investigate RF-EMF's mechanisms of action, which the authors propose could support development of non-invasive therapeutic applications.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Costantini E, Aielli L, Serra F, De Dominicis L, Falasca K, Di Giovanni P, Reale M (2022). Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model.
Show BibTeX
@article{costantini_e_aielli_l_serra_f_de_dominicis_l_falasca_k_di_giovanni_p_reale_m_ce2724,
  author = {Costantini E and Aielli L and Serra F and De Dominicis L and Falasca K and Di Giovanni P and Reale M},
  title = {Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model},
  year = {2022},
  doi = {10.1016/S0140-6736(22)01846-3},
  
}
DOI: 10.1016/S0140-6736(22)01846-3PubMed: 35216321

Quick Questions About This Study

This appears to be a database categorization error. The study examines hospital surgery capacity during COVID-19 and contains no EMF-related content, measurements, or findings related to electromagnetic field exposure.
No, this study measures surgical preparedness indicators like facilities, staffing, and systems capacity. It contains no electromagnetic field measurements, EMF sources, or radiation exposure assessments of any kind.
The index measured 23 hospital indicators including facilities, consumables, staffing levels, surgical prioritization systems, and operational capacity. Hospitals scored 23-115 points, with higher scores correlating to better surgical volume maintenance during COVID-19.
Only 415 hospitals (25.4%) maintained their expected surgical volume ratio during the pandemic. The remaining 1,217 hospitals (74.6%) experienced reduced elective surgery capacity compared to pre-pandemic 2019 levels.
Each 10-point increase in the surgical preparedness index corresponded to a 3.6% increase in maintained surgical volume ratio. This relationship held consistent across high-income, middle-income, and low-income country settings.