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Brain & Nervous System

Effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration

No Effects Found

de Gannes FP, Billaudel B, Taxile M, Haro E, Ruffié G, Lévêque P, Veyret B, Lagroye I · 2009

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The study did not confirm previous findings of blood-brain barrier leakage or neuronal degeneration after GSM-900 exposure.

Plain English Summary

Summary written for general audiences

In the study, 16 Fischer 344 rats (14 weeks old) were exposed head-only to the GSM-900 signal for 2 h at various brain-averaged SARs (0, 0.14 and 2.0 W/kg) or were used as cage or positive controls. Albumin leakage and neuron degeneration were evaluated 14 and 50 days after exposure. No statistically significant albumin leakage was observed. Neuronal degeneration assessed using cresyl violet or Fluoro-Jade B was not significantly different among the tested groups. No apoptotic neurons were found 14 days after the last exposure using the TUNEL method.

Why This Matters

The study aimed to perform a confirmation study of Salford et al. 2003 and investigate effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration. The findings of the study did not confirm the previous results of Salford et al.

Exposure Details

SAR
0.14 and 2 W/kg
Source/Device
900 MHz GSM
Exposure Duration
continuous for 2 hr

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.14 and 2 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 11 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to perform a confirmation study of Salford et al. 2003 and thus investigate effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration.

In our study, 16 Fischer 344 rats (14 weeks old) were exposed head-only to the GSM-900 signal for 2...

No apoptotic neurons were found 14 days after the last exposure using the TUNEL method. No statistic...

The findings of our study did not confirm the previous results of Salford et al

Cite This Study
de Gannes FP, Billaudel B, Taxile M, Haro E, Ruffié G, Lévêque P, Veyret B, Lagroye I (2009). Effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration Radiat Res. 172(3):359-367, 2009.
Show BibTeX
@article{fp_2009_effects_of_headonly_exposure_2747,
  author = {de Gannes FP and Billaudel B and Taxile M and Haro E and Ruffié G and Lévêque P and Veyret B and Lagroye I},
  title = {Effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration},
  year = {2009},
  
  url = {https://meridian.allenpress.com/radiation-research/article-abstract/172/3/359/42956},
}

Quick Questions About This Study

Sixteen Fischer 344 rats were exposed head-only to the GSM-900 signal for 2 hours at brain-averaged SARs of 0, 0.14, and 2.0 W/kg.
Albumin leakage and neuron degeneration were evaluated 14 and 50 days after exposure.
No statistically significant albumin leakage was observed.
Neuronal degeneration assessed with cresyl violet or Fluoro-Jade B was not significantly different among the tested groups.
The findings of the study did not confirm the previous results of Salford et al.