Decreasing Bone Resorption by Inducing Anti-Osteoclastogenic IFN-γ and IL-10 Expression in the Spleen Through an Electromagnetic Field on LPS-Induced Osteoporosis Mice
Authors not listed · 2025
Pulsed electromagnetic field therapy reduced inflammatory cytokines and enhanced IFN-γ and IL-10 expression in the spleen, alleviating bone loss in LPS-induced osteoporosis mice.
Plain English Summary
Researchers divided 40 mice into four groups to evaluate whether pulsed electromagnetic field (PEMF) therapy could inhibit bone resorption in a mouse model of lipopolysaccharide (LPS)-induced osteoporosis. Spleen tissue analysis demonstrated significant upregulation of IFN-γ and IL-10 expression in the PEMF group. Micro-CT and histological analysis confirmed that PEMF inhibited femoral bone loss and promoted bone regeneration in calvarial defects.
Why This Matters
The four groups were: control, LPS, LPS plus alendronate, and LPS plus PEMF. In the PEMF group, blood cytokine analysis showed reduced expression of TNF-α and IL-1β and increased expression of BMP-2. Compared with the control group, calcium levels in the PEMF group showed no significant difference.
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Show BibTeX
@article{decreasing_bone_resorption_by_inducing_anti_osteoclastogenic_ifn_and_il_10_expression_in_the_spleen_through_an_electromagnetic_field_on_lps_induced_osteoporosis_mice_ce4165,
author = {Unknown},
title = {Decreasing Bone Resorption by Inducing Anti-Osteoclastogenic IFN-γ and IL-10 Expression in the Spleen Through an Electromagnetic Field on LPS-Induced Osteoporosis Mice},
year = {2025},
doi = {10.3390/bioengineering12090923},
}