Molecular Mechanism of Malignant Transformation of Balb/c-3T3 Cells Induced by Long-Term Exposure to 1800 MHz Radiofrequency Electromagnetic Radiation (RF-EMR)
Ding Z, Xiang X, Li J, Wu S · 2022
Exposure to 1800 MHz RF-EMR for 40 and 60 days at a SAR of 8.0 W/kg induced malignant transformation in Balb/c-3T3 cells, increased proliferation and migration, and produced tumors in SCID mice.
Plain English Summary
Researchers exposed Balb/c-3T3 cells to 1800 MHz RF continuous wave for 40 and 60 days, 4 hours per day, and compared them with sham-exposed cells. Exposed cells showed increased proliferation and migration, malignant transformation with visible foci and clone formation, and formed tumors when transplanted into SCID mice.
Why This Matters
The study used a cell transformation assay, soft agar clone formation, transwell assay, and transplantation into SCID mice to assess malignant transformation. The authors suggested that interacted miRNAs could be further research targets for the carcinogenic mechanism of long-term exposure.
Show BibTeX
@article{ding_z_xiang_x_li_j_wu_s_ce2746,
author = {Ding Z and Xiang X and Li J and Wu S},
title = {Molecular Mechanism of Malignant Transformation of Balb/c-3T3 Cells Induced by Long-Term Exposure to 1800 MHz Radiofrequency Electromagnetic Radiation (RF-EMR)},
year = {2022},
}