Do 50/60 Hz magnetic fields influence oxidative or DNA damage responses in human SH-SY5Y neuroblastoma cells? Int J Radiat Biol 98(10):1581-1591, 2022
Mustafa E, Makinistian L, Luukkonen J, Juutilainen J, Naarala J · 2022
50 and 60 Hz magnetic field exposures produced minimal effects on oxidative stress and DNA damage in neuroblastoma cells, with only weak ROS signaling changes observed.
Plain English Summary
This 2022 in vitro study examined whether 50 and 60 Hz magnetic fields (at 100 µTRMS) affected oxidative stress, DNA damage, and related gene expression in human neuroblastoma cells. The researchers found only weak effects, including suggestive evidence of increased ROS-related gene expression and decreased menadione-induced ROS levels with 50 Hz exposure, while DNA damage and repair rates were unaffected.
Why This Matters
This study uses standard in vitro approaches (comet assay, RT-qPCR, fluorometric measurements) to assess biological responses to extremely low-frequency (ELF) magnetic fields. The use of menadione as an oxidative stress inducer and measurement of DNA repair kinetics provides mechanistic insight into potential cellular responses.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{do_5060_hz_magnetic_fields_influence_oxidative_or_dna_damage_responses_in_human_sh_sy5y_neuroblastoma_cells_int_j_radiat_biol_98101581_1591_2022_ce4163,
author = {Mustafa E and Makinistian L and Luukkonen J and Juutilainen J and Naarala J},
title = {Do 50/60 Hz magnetic fields influence oxidative or DNA damage responses in human SH-SY5Y neuroblastoma cells? Int J Radiat Biol 98(10):1581-1591, 2022},
year = {2022},
doi = {10.3390/life13030757},
}