Modulating effects of on-line low frequency electromagnetic fields on hippocampal long-term potentiation in young male Sprague- Dawley rat
Dong L, Zheng Y, Li ZY, Li G, Lin L · 2018
The study found that 100 Hz pulsed sinusoidal LF-EMFs acts as a modulator but does not induce long-term potentiation in male Sprague-Dawley rat hippocampal slices.
Plain English Summary
Researchers developed a novel patch-clamp setup for on-line LF-EMF stimulation. They applied magnetic fields of 0.5, 1, and 2 mT at 15, 50, and 100 Hz to study effects on synaptic plasticity. The slope of field excitatory postsynaptic potentials decreased significantly under priming on-line uninterrupted or pulsed sinusoidal LF-EMF stimulation. The study investigated whether LF-EMFs can induce long-term potentiation in male Sprague-Dawley rat hippocampal slices in vitro. Results showed that 100 Hz pulsed sinusoidal LF-EMFs acts only as a modulator, not an inducer of long-term potentiation.
Why This Matters
The researchers performed computational simulations of the stimulation coils to describe the uniformity of the on-line magnetic field distribution. Standard methods required moving brain slices from an exposure system to a recording chamber for electrophysiological recording.
Show BibTeX
@article{dong_l_zheng_y_li_zy_li_g_lin_l_ce4359,
author = {Dong L and Zheng Y and Li ZY and Li G and Lin L},
title = {Modulating effects of on-line low frequency electromagnetic fields on hippocampal long-term potentiation in young male Sprague- Dawley rat},
year = {2018},
}