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Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod

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Duan Y, Wang Z, Zhang H, He Y, Fan R, Cheng Y, Sun G, Sun X · 2014

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ELF electromagnetic field exposure impaired cognitive function in mice through specific molecular mechanisms in the hippocampus, which was reversible with lotus seedpod-derived procyanidins.

Plain English Summary

Summary written for general audiences

This study examined the effects of extremely low frequency (ELF) electromagnetic field exposure on cognitive function in mice, investigating mechanisms involving glutamate levels, MAPK pathway activation, and CREB phosphorylation in the hippocampus. The researchers found that ELF exposure caused cognitive impairment through these molecular alterations, and that procyanidins extracted from lotus seedpods could reverse these effects.

Why This Matters

The study investigates potential mechanisms of ELF-EMF effects on the central nervous system by examining key signaling pathways (MAPK and CREB phosphorylation) and neurotransmitter levels known to be important for learning and memory. The proposed reversal using a plant-derived compound suggests the mechanisms may involve oxidative stress or related cellular processes.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Duan Y, Wang Z, Zhang H, He Y, Fan R, Cheng Y, Sun G, Sun X (2014). Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod.
Show BibTeX
@article{duan_y_wang_z_zhang_h_he_y_fan_r_cheng_y_sun_g_sun_x_ce4361,
  author = {Duan Y and Wang Z and Zhang H and He Y and Fan R and Cheng Y and Sun G and Sun X},
  title = {Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod},
  year = {2014},
  doi = {10.1088/1674-1137/41/1/013002},
  
}
DOI: 10.1088/1674-1137/41/1/013002

Quick Questions About This Study

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