Effects of 50-Hz magnetic field exposure on hormone secretion and apoptosis-related gene expression in human first trimester villous trophoblasts in vitro
Authors not listed · 2010
Exposure to a 50-Hz magnetic field at 0.4 mT for 72 hours significantly inhibited hCG and progesterone secretion in human first trimester trophoblasts.
Plain English Summary
Researchers isolated trophoblasts from first trimester human chorionic villi and exposed them to a 50-Hz magnetic field for different durations. Exposure at 0.2 mT for 72 hours did not affect hCG and progesterone secretion. Exposure at 0.4 mT for 48 hours showed no significant change in hormone secretion. Exposure at 0.4 mT for 72 hours significantly inhibited hCG and progesterone secretion. Apoptosis-related gene expression (bcl-2, bax, caspase-3, p53, fas) did not differ after 72 hours at 0.4 mT.
Why This Matters
The study was motivated by evidence that extremely low frequency magnetic fields could produce deleterious effects on reproduction. Hormone levels were measured using electrochemiluminescence immunoassay. The authors suggested that longer magnetic field exposure could inhibit hormone secretion without involving trophoblast apoptosis.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{effects_of_50_hz_magnetic_field_exposure_on_hormone_secretion_and_apoptosis_related_gene_expression_in_human_first_trimester_villous_trophoblasts_in_vitro_ce2137,
author = {Unknown},
title = {Effects of 50-Hz magnetic field exposure on hormone secretion and apoptosis-related gene expression in human first trimester villous trophoblasts in vitro},
year = {2010},
doi = {10.1002/bem.20596},
}