Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair
Authors not listed · 2010
Static magnetic fields produced some statistically significant differences in DNA damage in leukocytes, but pre-irradiation SMF exposure showed no significant effect on radiation-damaged DNA repair.
Plain English Summary
This study investigated whether static magnetic fields (SMFs) influence DNA or the repair of radiation-damaged DNA in leukocytes. Samples were exposed to inhomogeneous SMFs with lateral magnetic flux density gradients of 47.7, 1.2, or 0.3 T/m, or to a homogeneous SMF of 159.2 ± 13.4 mT, for time periods ranging from 0.5 minutes to 24 hours. DNA damage was measured using the single-cell gel electrophoresis technique, also called the comet assay. When SMF exposure preceded gamma irradiation, no statistically significant difference in DNA damage was found compared to the 4 Gy gamma-irradiated group.
Why This Matters
Three exposure scenarios were tested: SMF alone, SMF applied after gamma irradiation, and SMF applied before gamma irradiation. When samples received SMF only, statistically significant differences in DNA damage compared to control were found at 1 hour for inhomogeneous SMF and at 4 and 18 hours for homogeneous SMF. When SMF followed irradiation with 4 Gy of gamma radiation, statistically significant differences were found at 1 hour for inhomogeneous SMF and at 4 hours for homogeneous SMF. When SMF was applied before gamma irradiation, no statistically significant difference was detected compared to the irradiated group alone.
Show BibTeX
@article{effects_of_homogeneous_and_inhomogeneous_static_magnetic_fields_combined_with_gamma_radiation_on_dna_and_dna_repair_ce4087,
author = {Unknown},
title = {Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair},
year = {2010},
doi = {10.1002/bem.20577},
}