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EFFECTS OF HYPERTHERMIA AND MICROWAVE INDUCED HYPERTHERMIC SHOCK ON HPC CELLS

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Rapid microwave heating (9.2°C/s) and slow water bath heating (0.22°C/s) had only a small difference in effect on human prostate cancer cells at 43.5 to 47.5°C.

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Researchers compared slow water bath heating (0.22°C/s) with rapid microwave heating (9.2°C/s) prior to 15 minute hyperthermic exposures of human prostate cancer cells in vitro, and found the effect of heating rate to be small in the 43.5-47.5°C exposure range. Microwave-induced hyperthermic shock (an exposure of a few seconds above 37°C followed by immediate water bath cooling) had no effect on cell survival below 43°C, and above that temperature survival decreased with increasing exposure temperature.

Why This Matters

This study compared slow water bath heating with rapid microwave heating of human prostate cancer cells in vitro. Heating at 9.2°C/s by microwave and at 0.22°C/s in a water bath differed little in effect in the 43.5-47.5°C exposure range. Microwave-induced hyperthermic shock had no effect on survival below 43°C, and between 43 and 50°C survival followed the linear relationship S = -11.6Tp + 593 with a correlation coefficient r = 0.95. Effects were assayed by cellular attachment and colony formation and also shown by SEM photography.

Cite This Study
Unknown (n.d.). EFFECTS OF HYPERTHERMIA AND MICROWAVE INDUCED HYPERTHERMIC SHOCK ON HPC CELLS.
Show BibTeX
@article{effects_of_hyperthermia_and_microwave_induced_hyperthermic_shock_on_hpc_cells_g7274,
  author = {Unknown},
  title = {EFFECTS OF HYPERTHERMIA AND MICROWAVE INDUCED HYPERTHERMIC SHOCK ON HPC CELLS},
  year = {n.d.},
  
  
}
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Quick Questions About This Study

Heating rate had only a small effect in the 43.5-47.5°C exposure range, comparing water bath heating at 0.22°C/s with microwave heating at 9.2°C/s. Microwave hyperthermic shock followed by immediate water bath cooling had no effect on cell survival below 43°C, and above 43°C survival decreased linearly with exposure temperature.
Microwave thermal shock had no effect on human prostate cancer cell survival below 43°C. Above this temperature, cell survival decreased linearly according to S = -11.6Tp + 593 (43 < Tp < 50°C), with a correlation coefficient r = 0.95.
Microwave heating occurred at 9.2°C per second, over 40 times faster than the water bath heating rate of 0.22°C per second. The effect of this difference in heating rate was small in the 43.5-47.5°C exposure range.
No, the microwave thermal shock exposures lasted only a few seconds above 37°C body temperature, followed by immediate water bath cooling. Below 43°C they had no effect on cell survival, and above that temperature survival decreased with increasing exposure temperature.
Effects were assayed by cellular attachment and colony formation, and they are also shown by scanning electron microscopy (SEM) photography.