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Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.

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Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T, Kim HC. · 2007

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Exposure to extremely low frequency magnetic fields enhanced locomotor activity in mice, an effect that was blocked by a dopamine D1-like receptor antagonist.

Plain English Summary

Summary written for general audiences

Researchers examined the role of dopaminergic receptors in behavioral changes induced by extremely low frequency magnetic fields (ELF-MF). Exposure to ELF-MF at 2.4 mT for 1 hour per day, for one or seven days, enhanced locomotor activity in a time-dependent manner. The results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.

Why This Matters

The study built on earlier work showing that ELF-MF enhanced dopamine levels in the rat striatum. The increase in locomotor activity was accompanied by an increase in c-Fos-like immunoreactivity. Blocking D1-like receptors with SCH23390 inhibited both the increased locomotor activity and the c-Fos-IR response, while blocking D2-like receptors with sulpiride did not.

Exposure Details

Magnetic Field
2.4 mT
Exposure Duration
1 h/day, for one or seven days

Exposure Context

This study used 2.4 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2.4 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 12 times the FCC limit

Study Details

We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum

To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behav...

Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-d...

Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D(1)-like receptors.

Cite This Study
Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T, Kim HC. (2007). Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J Pharmacol Sci. 105(4):367-371, 2007.
Show BibTeX
@article{ej_2007_exposure_to_extremely_low_300,
  author = {Shin EJ and Jeong JH and Kim HJ and Jang CG and Yamada K and Nabeshima T and Kim HC.},
  title = {Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.},
  year = {2007},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/18094524/},
}
PubMed: 18094524

Cited By (31 papers)

Quick Questions About This Study

The exposure was 2.4 mT for 1 hour per day, lasting for one or seven days.
Exposure enhanced locomotor activity in a time-dependent manner.
The results suggest the behavioral responses were, at least in part, mediated by activation of dopamine D1-like receptors.
Sulpiride, a dopaminergic D2-like receptor antagonist, did not inhibit the ELF-MF-induced increased locomotor activity.
The hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity.