ENHANCEMENT OF CANCER CHEMOTHERAPY BY SELECTIVE ELECTROMAGNETIC HEATING OF TUMORS
H. A. Ecker, C. P. Burns, R. L. Magin, V. P. Popovic · 1971
Differential hypothermia with selective electromagnetic heating produced significant tumor regression in mice and rats treated with chemotherapy.
Plain English Summary
In the differential hypothermia technique, the whole animal was cooled to 40-50°F and electromagnetic radiation heated the tumor to approximately 98°F. Cooled healthy tissues utilized very little of the anticancer drug while the warm tumor with high metabolic rate was affected to a much higher degree. Mice with spontaneous tumors treated with 5-fluorouracil and differential hypothermia showed significant tumor regression after several hours. Rats with chemically induced tumors showed tumor regression in all cases after differential hypothermia and chemotherapy. A technique using 3-30 MHz radiation with ferrite or magnetic stainless steel doping was developed for heating deep tumors such as in the brain.
Why This Matters
The differential hypothermia technique was first developed at Emory University and termed warm tumor - cold body treatment. Penetration depth at these frequencies is much greater than at microwave frequencies, and the radiation will penetrate the whole body. Ferrite doping particles as small as ten microns can be injected instead of surgery. The approach will improve the effectiveness of known anticancer drugs while reducing harmful effects on healthy tissues.
Show BibTeX
@article{enhancement_of_cancer_chemotherapy_by_selective_electromagnetic_heating_of_tumor_g3973,
author = {H. A. Ecker and C. P. Burns and R. L. Magin and V. P. Popovic},
title = {ENHANCEMENT OF CANCER CHEMOTHERAPY BY SELECTIVE ELECTROMAGNETIC HEATING OF TUMORS},
year = {1971},
}