Exposure of Fischer 344 rats to a weak power frequency magnetic field facilitates mammary tumorigenesis in the DMBA model of breast cancer
Authors not listed · 2008
MF exposure at 100 muT, 50 Hz for 26 weeks increased mammary adenocarcinoma incidence by 45% in DMBA-treated Fischer 344 rats.
Plain English Summary
Researchers exposed groups of 108 DMBA-treated Fischer 344 rats to a 100 muT, 50 Hz magnetic field or sham exposure for 26 weeks. MF exposure significantly facilitated mammary tumorigenesis. The incidence of histologically verified adenocarcinomas was increased by 45% (P = 0.0095). The most pronounced effect on tumor incidence was seen in the cranial inguinal complexes.
Why This Matters
Previous DMBA model studies in Sprague-Dawley rats had been inconclusive due to substrain differences in magnetic field sensitivity. The researchers had found that Fischer 344 was the only inbred strain showing a marked increase in mammary cell proliferation after magnetic field exposure. The authors conclude that Fischer 344 rats are a suitable inbred strain for studying mechanisms of magnetic field effects on mammary tumorigenesis.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{exposure_of_fischer_344_rats_to_a_weak_power_frequency_magnetic_field_facilitates_mammary_tumorigenesis_in_the_dmba_model_of_breast_cancer_ce1431,
author = {Unknown},
title = {Exposure of Fischer 344 rats to a weak power frequency magnetic field facilitates mammary tumorigenesis in the DMBA model of breast cancer},
year = {2008},
doi = {10.1093/carcin/bgm217},
}