Exposure of mcf-7 breast cancer cells to electromagnetic fields up-regulates the plasminogen activator system
Authors not listed · 2009
Exposure of MCF-7 breast cancer cells to 50-Hz EMF at 1.2 microT markedly increased urokinase plasminogen activator and plasminogen-activator inhibitor-1 gene expression.
Plain English Summary
Researchers exposed MCF-7 breast cancer cells from two sources to homogeneous 50-Hz electromagnetic fields at 1.2 microT. Gene expression was measured using reverse transcriptase-polymerase chain reaction. Exposure markedly increased urokinase plasminogen activator and plasminogen-activator inhibitor-1 expression, marginally increased the urokinase receptor in one cell line, and slightly decreased tissue plasminogen activator expression. The authors suggest that EMFs may increase the metastatic potential of breast tumors.
Why This Matters
The authors note that their newly established exposure system may allow study of signaling processes involved in metastatic phenotype induction. They also mention that epidemiological studies have proposed effects of EMFs on breast cancer incidence.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{exposure_of_mcf_7_breast_cancer_cells_to_electromagnetic_fields_up_regulates_the_plasminogen_activator_system_ce1401,
author = {Unknown},
title = {Exposure of mcf-7 breast cancer cells to electromagnetic fields up-regulates the plasminogen activator system},
year = {2009},
doi = {10.1111/IGC.0b013e31819f53ec},
}