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Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude

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Authors not listed · 2022

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Exposure to a 1.8 GHz carrier frequency at household telecommunications amplitude induces ROS formation in human HEK293 cells, with significant increase after 15 minutes and evidence of hormetic dose-response.

Plain English Summary

Summary written for general audiences

Researchers exposed human HEK293 cultured cells to a 1.8 GHz carrier frequency at amplitudes typical of household telecommunications. ROS concentrations increased significantly after 15 minutes of exposure and were localized to both nuclear and cytosolic compartments. qPCR analysis revealed altered gene expression of anti-oxidative enzymes SOD, GPX, and CAT, and oxidative enzyme Nox-2. Multiple genes responsive to static magnetic fields were also regulated by RF, suggesting common response mechanisms. Many RF effects showed evidence of hormesis with biphasic dose-response curves and blind spots at certain amplitudes.

Why This Matters

The authors conclude that modulation of intracellular ROS can be a direct consequence of RF exposure dependent on signal frequency and amplitude. They suggest that since changes in intracellular ROS may have both harmful and beneficial effects, these could provide the basis for many reported physiological effects of RF exposure.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.8 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.8 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2022). Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude.
Show BibTeX
@article{exposure_to_18_ghz_radiofrequency_field_modulates_ros_in_human_hek293_cells_as_a_function_of_signal_amplitude_ce2568,
  author = {Unknown},
  title = {Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude},
  year = {2022},
  doi = {10.1080/19420889.2022.2027698},
  
}
DOI: 10.1080/19420889.2022.2027698PubMed: 35126804

Quick Questions About This Study

The study used a 1.8 GHz carrier frequency at amplitudes typical of household telecommunications.
ROS concentrations increased significantly after 15 minutes of RF field exposure and were localized to both nuclear and cytosolic compartments.
qPCR analysis showed altered expression of anti-oxidative enzymes SOD, GPX, and CAT, and oxidative enzyme Nox-2.
Many RF effects showed evidence of hormesis with biphasic dose-response curves and blind spots at certain signal amplitudes where no measurable response occurred.
The authors conclude that modulation of intracellular ROS can be a direct consequence of RF exposure dependent on signal frequency and amplitude, and that ROS changes may have both harmful and beneficial effects underlying reported physiological effects.