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Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

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Authors not listed · 2023

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In rats exposed to both EMF and fructose, hypothalamic metabolic regulators and antioxidant activities were significantly decreased versus normal, EMF-only, and fructose-only groups, while hepatic regulators were significantly reduced versus the normal group.

Plain English Summary

Summary written for general audiences

Weaned Wistar rats were divided into four groups and exposed to EMF (1,760 MHz, 2 h/day) and/or 15% fructose solution for 8 weeks. In the hypothalamic tissue of the combined exposure group, expressions of SIRT1, FOXO1, p-PI3K, p-AKT, Complex III, UCP2, MnSOD, and catalase and activities of OXPHOS and GSH were significantly decreased compared to the normal, EMF-only, and fructose-only groups. In hepatic tissue of the combined exposure group, expressions of p-AMPKα, SIRT1, FOXO1, IRS1, p-PI3K, Complex I, II, III, IV, V, UCP2, and MnSOD and activities of OXPHOS, SOD, catalase, and GSH were significantly reduced compared to the normal group.

Why This Matters

Mitochondrial function, insulin receptor signaling, and oxidative stress signals were assessed in hypothalamic and hepatic tissues using western blotting and biochemical analysis. The findings suggest that combined EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts insulin receptor signals, mitochondrial OXPHOS, and antioxidant defense in the hypothalamus and liver.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1760 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1760 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2023). Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats.
Show BibTeX
@article{exposure_to_electromagnetic_fields_from_mobile_phones_and_fructose_consumption_coalesce_to_perturb_metabolic_regulators_ampksirt1_ucp2foxo1_in_growing_rats_ce2621,
  author = {Unknown},
  title = {Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats},
  year = {2023},
  doi = {10.3967/bes2023.134},
  
}
DOI: 10.3967/bes2023.134PubMed: 38098324

Quick Questions About This Study

The EMF exposure was 1,760 MHz for 2 hours per day over 8 weeks, and the fructose solution was 15%.
In hypothalamic tissue of the combined exposure group, expressions of SIRT1, FOXO1, p-PI3K, p-AKT, Complex III, UCP2, MnSOD, and catalase and activities of OXPHOS and GSH were significantly decreased compared to the normal, EMF-only, and fructose-only groups.
In hepatic tissue of the combined exposure group, expressions of p-AMPKα, SIRT1, FOXO1, IRS1, p-PI3K, Complex I, II, III, IV, V, UCP2, and MnSOD and activities of OXPHOS, SOD, catalase, and GSH were significantly reduced compared to the normal group.
The findings suggest that combined EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts insulin receptor signals, mitochondrial OXPHOS, and antioxidant defense in the hypothalamus and liver.
Weaned Wistar rats were divided into four groups: normal, EMF only, fructose only, and combined EMF and fructose, and were fed standard chow for 8 weeks.