6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Cellular Effects

Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure: role of reactive oxygen species.

Bioeffects Seen

Zhao G, Chen S, Wang L, Zhao Y, Wang J, Wang X, Zhang W, Wu R, Wu L, Wu Y, Xu A · 2011

View Original Abstract
Share:

ATP content was significantly decreased in human-hamster hybrid cells exposed to an 8.5 Tesla static magnetic field, with reactive oxygen species involved in the effect.

Plain English Summary

Summary written for general audiences

The study examined cellular effects of a strong homogeneous static magnetic field in human-hamster hybrid (AL) cells, mitochondria-deficient cells, and double-strand break repair-deficient cells. ATP content was significantly decreased in AL cells exposed to 8.5 Tesla but not 1 or 4 T static magnetic field for either 3 or 5 hours. Reactive oxygen species levels were significantly increased by 8.5 T exposure, and concurrent treatment with the ROS inhibitor DMSO dramatically suppressed the ATP content in exposed AL cells. Mutation frequency and cell cycle distribution were not significantly affected by 8.5 T exposure for 3 hours.

Why This Matters

The ATP drop appeared to depend on field strength, since 1 T and 4 T exposures did not produce a significant decrease. In normal AL cells, ATP levels recovered to the control level after 12 or 24 hours without exposure, but the deficient cell lines did not recover. The researchers concluded that the ATP reduction was partially mediated by mitochondria and the DNA DSB repair process.

Exposure Details

Magnetic Field
1000, 4000, 8500 mT
Exposure Duration
3 or 5 h

Exposure Context

This study used 1000, 4000, 8500 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1000, 4000, 8500 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 5,000 times the FCC limit

Study Details

The present study focused on the cellular effects of strong homogeneous SMF in human–hamster hybrid (AL) cells, mitochondria-deficient (ρ0 AL) cells, and double-strand break (DSB) repair-deficient (XRS-5) cells.

Adenosine triphosphate (ATP) content was significantly decreased in AL cells exposed to 8.5 Tesla (T...

Our results indicated that the cellular ATP content was reduced by 8.5 T SMF for 3 h exposure, which was partially mediated by mitochondria and the DNA DSB repair process. Moreover, ROS were involved in the process of the cellular perturbations from the SMF.

Cite This Study
Zhao G, Chen S, Wang L, Zhao Y, Wang J, Wang X, Zhang W, Wu R, Wu L, Wu Y, Xu A (2011). Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure: role of reactive oxygen species. Bioelectromagnetics. 32(2):94-101, 2011.
Show BibTeX
@article{g_2011_cellular_atp_content_was_491,
  author = {Zhao G and Chen S and Wang L and Zhao Y and Wang J and Wang X and Zhang W and Wu R and Wu L and Wu Y and Xu A},
  title = {Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure: role of reactive oxygen species.},
  year = {2011},
  doi = {10.1002/bem.20617},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20617},
}
DOI: 10.1002/bem.20617

Cited By (40 papers)

Quick Questions About This Study

A significant decrease in ATP was found at 8.5 Tesla but not at 1 or 4 Tesla.
ATP content returned to the control level in AL cells after 12 or 24 hours without exposure, but did not recover in ρ0 AL and XRS-5 cells.
Concurrent treatment with the ROS inhibitor DMSO dramatically suppressed the ATP content in exposed AL cells.
Neither CD59 mutation frequency nor cell cycle distribution was significantly affected by exposure to 8.5 T for 3 hours.
The study used human-hamster hybrid (AL) cells, mitochondria-deficient (ρ0 AL) cells, and double-strand break (DSB) repair-deficient (XRS-5) cells.