Gene expression in human breast epithelial cells exposed to 60 Hz magnetic fields
Authors not listed · 1999
These results suggest that EMF is unlikely to influence breast cancer induction through a mechanism involving altered expression of these genes.
Plain English Summary
Researchers exposed HBL-100 cells and normal human mammary epithelial cells to 60 Hz EMF at flux densities of 0.1, 1.0, and 10.0 Gauss for periods ranging from 20 min to 24 h. Gene expression was quantitated using ribonuclease protection assays. EMF exposure had no statistically significant effect on basal levels of c-myc transcripts in either human breast cell model, and had no effect on alterations in c-myc expression induced by 12-O-tetradecanoylphorbol-13-acetate. Transcript levels of c-erbB-2, p53, p21, GADD45, bax, bcl-x, mcl-1, and c-fos were also unaffected by EMF exposure.
Why This Matters
Epidemiology suggests a possible relationship between exposure to power frequency magnetic fields (EMF) and breast cancer. One mechanism through which EMF could stimulate breast cancer induction is via altered expression of oncogenes and/or tumor suppressor genes that regulate normal and neoplastic growth. These results suggest that EMF is unlikely to influence breast cancer induction through a mechanism involving altered expression of these genes.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{gene_expression_in_human_breast_epithelial_cells_exposed_to_60_hz_magnetic_fields_ce1558,
author = {Unknown},
title = {Gene expression in human breast epithelial cells exposed to 60 Hz magnetic fields},
year = {1999},
doi = {10.1093/CARCIN/20.8.1633},
}