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Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats

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Goudarzi M, Asl JF, Shoghi H · 2023

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Rosmarinic acid demonstrated protective effects against electromagnetic radiation-induced cardiotoxicity by restoring antioxidant enzyme activity and reducing oxidative stress markers in rat cardiac tissue.

Plain English Summary

Summary written for general audiences

This study examined whether rosmarinic acid (RA), a plant-based antioxidant, could protect against cardiotoxicity induced by electromagnetic radiation (EMR) at 915 MHz and 2450 MHz frequencies in rats over 30 days. The results showed that EMR exposure significantly increased oxidative stress markers and reduced antioxidant defenses, while RA treatment reversed these effects and provided significant cardiac protection.

Why This Matters

The study mechanisms align with established EMR-induced oxidative stress pathways, where ROS accumulation depletes endogenous antioxidant systems. The use of specific frequency ranges (915 and 2450 MHz) relevant to cellular communications provides relevant exposure conditions, though the findings are from animal models and require validation in human studies.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Goudarzi M, Asl JF, Shoghi H (2023). Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats.
Show BibTeX
@article{goudarzi_m_asl_jf_shoghi_h_ce2387,
  author = {Goudarzi M and Asl JF and Shoghi H},
  title = {Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats},
  year = {2023},
  doi = {10.1016/s2542-5196(23)00053-0},
  
}
DOI: 10.1016/s2542-5196(23)00053-0PubMed: 38146407

Quick Questions About This Study

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