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Evaluation of Oxidative Stress and Genetic Instability Among Residents Near Mobile Phone Base Stations in Germany

No Effects Found

Gulati S, Mosgoeller W, Moldan D, Kosik P, Durdik M, Jakl L, Skorvaga M, Markova E, Kochanova D, Vigasova K, Belyaev I · 2024

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Residents with higher long-term exposure to RF-EMF from mobile phone base stations showed significantly more chromosomal aberrations, while MLL gene rearrangements and oxidative DNA lesions were not significantly affected.

Plain English Summary

Summary written for general audiences

Researchers identified two neighboring housing estates with relatively low or high RF-EMF from nearby mobile phone base stations and 24 healthy adults who had lived in their homes for at least five years volunteered. Homes were surveyed for EMF and blood samples were tested for oxidative status, DNA alterations, chromosomal damage, and cancer-related genetic markers such as MLL gene rearrangements. Long-term exposure had no measurable effect on MLL gene rearrangements or c-Abl-gene transcription, and lipid oxidation and oxidative DNA lesions were higher but not statistically significant. Dicentric chromosomes, chromatid gaps, chromosomal fragments, and total chromosomal aberrations were significantly higher in the exposed group. No potential confounder interfered with these findings.

Why This Matters

The groups were well matched for age, sex, lifestyle, and occupational risk factors, and the researchers documented possible confounders such as nutrition and prior ionizing radiation exposure. DNA double strand breaks, micronuclei, ring chromosomes, and acentric chromosomes did not differ significantly between groups. The authors suggest that increased chromosomal aberration rates linked to ionizing radiation may also occur with non-ionizing radiation exposure. They propose that chromosomal aberrations could help define protection thresholds for non-ionizing radiation, as they reflect exposure intensity and duration.

Cite This Study
Gulati S, Mosgoeller W, Moldan D, Kosik P, Durdik M, Jakl L, Skorvaga M, Markova E, Kochanova D, Vigasova K, Belyaev I (2024). Evaluation of Oxidative Stress and Genetic Instability Among Residents Near Mobile Phone Base Stations in Germany.
Show BibTeX
@article{gulati_s_mosgoeller_w_moldan_d_kosik_p_durdik_m_jakl_l_skorvaga_m_markova_e_kochanova_d_vigasova_k_belyaev_i_ce2391,
  author = {Gulati S and Mosgoeller W and Moldan D and Kosik P and Durdik M and Jakl L and Skorvaga M and Markova E and Kochanova D and Vigasova K and Belyaev I},
  title = {Evaluation of Oxidative Stress and Genetic Instability Among Residents Near Mobile Phone Base Stations in Germany},
  year = {2024},
  doi = {10.1016/j.ecoenv.2024.116486},
  
}

Quick Questions About This Study

Researchers identified two neighboring housing estates with relatively low or high RF-EMF from nearby mobile phone base stations and 24 healthy adults who had lived in their homes for at least five years volunteered.
Homes were surveyed for EMF and blood samples were tested for oxidative status, transient DNA alterations, permanent chromosomal damage, and specific cancer related genetic markers like MLL gene rearrangements.
The years long exposure had no measurable effect on MLL gene rearrangements and c-Abl-gene transcription modification.
Chromosomal aberrations like dicentric chromosomes (p=0.007), chromatid gaps (p=0.019), chromosomal fragments (p<0.001) and the total of chromosomal aberrations (p<0.001) were significantly higher in the exposed group.
The groups matched well for age, sex, lifestyle, and occupational risk factors, and the researchers documented possible confounders such as nutrition and ionizing radiation exposure. No potential confounder interfered with the findings.