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Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica

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Gupta V, Srivastava R · 2024

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Ashwagandha root extract reduced microwave radiation-induced hippocampal apoptosis and oxidative stress through enhancement of cholinergic balance and antioxidant enzyme activity in an avian model.

Plain English Summary

Summary written for general audiences

This study examined how microwave radiation (MWR) exposure affects oxidative stress and neurodegeneration in the hippocampus of male Japanese quail, and whether Ashwagandha (ASW) treatment could mitigate these effects. The results showed that MWR induced oxidative stress, neuro-inflammation, and apoptosis in hippocampal neurons, while ASW treatment reduced ROS production, prevented neurodegeneration, and restored cholinergic balance.

Why This Matters

This study uses an animal model (Japanese quail) to investigate potential neuroprotective mechanisms rather than direct human health effects. The findings suggest a potential biological pathway through which oxidative stress and neuroinflammation could mediate microwave radiation effects, though extrapolation to human exposure and relevance at typical environmental exposure levels would require further investigation.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Gupta V, Srivastava R (2024). Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica.
Show BibTeX
@article{gupta_v_srivastava_r_ce2397,
  author = {Gupta V and Srivastava R},
  title = {Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica},
  year = {2024},
  doi = {10.1093/jbmrpl/ziae120},
  
}
DOI: 10.1093/jbmrpl/ziae120PubMed: 38506951

Quick Questions About This Study

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