Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica
Gupta V, Srivastava R · 2024
Microwave radiation induces apoptosis and oxidative stress in the brain, while ashwagandha reduces excessive ROS production, prevents neurodegeneration, and promotes neuronal health.
Plain English Summary
The study used a control group, a microwave radiation group exposed for 2 h/day for 30 days, an ashwagandha group given 100 mg/day/kg body weight, and a combined exposure group. Microwave radiation increased serum corticosterone levels, disrupted cholinergic balance, and induced neuro-inflammation. Neuro-inflammation led to oxidative stress, as shown by decreased activity of the antioxidant enzymes SOD, CAT, and GSH. Microwave radiation also caused a significant decline in nissil substances in the hippocampus, indicating neurodegeneration through oxidative stress mediated hippocampal apoptosis. Ashwagandha reduced ROS production by increasing ROS-scavenging enzyme activity and decreased caspase-3 and caspase-7 expression, promoting neuronal health.
Show BibTeX
@article{gupta_v_srivastava_r_ce2397,
author = {Gupta V and Srivastava R},
title = {Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica},
year = {2024},
}