Amelioration and Immuno-modulation by Ashwagandha on Wi-fi Induced Oxidative Stress in Regulating Reproduction Via Estrogen Receptor Alpha in Male Japanese Quail
Gupta V, Srivastava R · 2025
Exposure to Wi-fi increased oxidative stress, activated apoptosis, and modulated immunity in the testis of male Japanese quail, while Ashwagandha reversed these effects via enhanced ERα expression and increased sperm count.
Plain English Summary
Researchers exposed 8-week-old male Japanese quail to 2.4 GHz Wi-fi radiation for 2 hours per day over 30 days and gave some birds oral Ashwagandha root extract at 100 mg/kg body weight. Wi-fi exposure decreased testicular weight, volume, density, and gonado-somatic index, while Ashwagandha increased these measures. Exposed quail showed increased oxidative stress parameters and reduced activity of SOD, catalase, and GSH in testes, and Ashwagandha treatment restored the redox balance. Wi-fi exposure raised corticosterone, lowered testosterone, and reduced estrogen receptor alpha expression in the testis. Wi-fi exposure increased IL1β and decreased IL10 in the testis, while Ashwagandha increased ERα expression, sperm count, and immunity, and decreased IL1β and NF-κB while increasing IL-10.
Why This Matters
IL-1β inhibits testicular cell function and promotes apoptosis in Wi-fi exposed quails. This occurs through increased NF-κB and decreased sperm count.
Show BibTeX
@article{gupta_v_srivastava_r_ce2398,
author = {Gupta V and Srivastava R},
title = {Amelioration and Immuno-modulation by Ashwagandha on Wi-fi Induced Oxidative Stress in Regulating Reproduction Via Estrogen Receptor Alpha in Male Japanese Quail},
year = {2025},
}