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Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica

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Gupta V, Srivastava R · 2024

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Ashwagandha root extract demonstrated neuroprotective effects against microwave radiation-induced hippocampal damage by reducing oxidative stress and apoptosis markers in an avian model.

Plain English Summary

Summary written for general audiences

This study examined how microwave radiation exposure affects oxidative stress and neurodegeneration in the hippocampus of male Japanese quail, and whether Ashwagandha root extract could provide protective effects. The results showed that microwave radiation increased inflammation, oxidative stress, and apoptosis in hippocampal neurons, while Ashwagandha treatment reduced these harmful effects by enhancing antioxidant enzyme activity and decreasing apoptosis markers.

Why This Matters

This study uses an avian model (Japanese quail) rather than a mammalian rodent model, despite the record classification. The proposed mechanism involves cholinergic balance and neuro-inflammatory pathways as intermediates in oxidative stress-induced neurodegeneration.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Gupta V, Srivastava R (2024). Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica.
Show BibTeX
@article{gupta_v_srivastava_r_ce3250,
  author = {Gupta V and Srivastava R},
  title = {Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica},
  year = {2024},
  doi = {10.1093/jbmrpl/ziae120},
  
}
DOI: 10.1093/jbmrpl/ziae120PubMed: 38506951

Quick Questions About This Study

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