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Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats.

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Nakamura H, Matsuzaki I, Hatta K, Nobukuni Y, Kambayashi Y, Ogino K · 2003

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Microwave radiation at higher intensities caused pregnancy-related biological effects beyond heating alone, suggesting non-thermal mechanisms exist.

Plain English Summary

Summary written for general audiences

Researchers exposed pregnant rats to cell phone-frequency radiation at different power levels. At higher exposure levels, the microwaves caused harmful effects on blood flow and hormones that heating alone did not produce, suggesting radiation has biological effects beyond just tissue heating.

Why This Matters

This study provides compelling evidence that microwave radiation can have biological effects that go beyond simple tissue heating. What makes this research particularly significant is its careful experimental design comparing microwave exposure to equivalent heating effects. The finding that higher-intensity microwave exposure caused reductions in blood flow and estradiol levels that weren't seen with heat alone demonstrates non-thermal mechanisms at work. The lower exposure level tested (0.6 mW/cm²) corresponds to the maximum exposure limit recommended by ANSI, which is comparable to levels from cell phones held close to the body. While the study found no non-thermal effects at this lower level, the clear biological impacts at higher intensities raise important questions about cumulative exposure and vulnerable populations like pregnant women.

Exposure Details

SAR
0.4 W/kg
Power Density
0.6 or 3 µW/m²
Source/Device
915 MHz
Exposure Duration
90 min

Exposure Context

This study used 0.6 or 3 µW/m² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.6 or 3 µW/m²Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the Slight Concern range (Building Biology)FCC limit is 16,666,667x higher than this exposure level

Study Details

To examine nonthermal effect of continuous wave (CW) 915 MHz microwaves used in cellular phones, we compared the effects of microwaves with those of heat.

Thirty-six pregnant rats were assigned to six groups: rats exposed to microwaves at 0.6 or 3 mW/cm2 ...

We identified significant differences in the uteroplacental circulation, and in placental endocrine ...

These results suggest microwaves at 0.6 mW/cm2 at 915 MHz, equal to a specific absorption rate (SAR) of 0.4 W/kg, which is the maximum permissible exposure level recommended by the American National Standards Institute (ANSI), do not exert nonthermal effects on blood estradiol and progesterone, on splenic natural killer cell activity, on the uteroplacental circulation.

Cite This Study
Nakamura H, Matsuzaki I, Hatta K, Nobukuni Y, Kambayashi Y, Ogino K (2003). Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats. Reprod Toxicol 2003 17(3):321-326, 2003.
Show BibTeX
@article{h_2003_nonthermal_effects_of_mobilephone_1219,
  author = {Nakamura H and Matsuzaki I and Hatta K and Nobukuni Y and Kambayashi Y and Ogino K},
  title = {Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats.},
  year = {2003},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0890623803000108},
}

Quick Questions About This Study

Researchers exposed pregnant rats to cell phone-frequency radiation at different power levels. At higher exposure levels, the microwaves caused harmful effects on blood flow and hormones that heating alone did not produce, suggesting radiation has biological effects beyond just tissue heating.