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Brain & Nervous System

1950 MHz IMT-2000 field does not activate microglial cells in vitro.

No Effects Found

Hirose H, Sasaki A, Ishii N, Sekijima M, Iyama T, Nojima T, Ugawa Y. · 2010

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Cell phone radiation up to 2.0 W/kg didn't activate brain immune cells in this lab study, suggesting no immediate inflammatory response.

Plain English Summary

Summary written for general audiences

Researchers exposed brain immune cells called microglia to cell phone radiation at levels up to 2.0 W/kg for two hours to see if it would activate an inflammatory response. They found no signs of activation or increased production of inflammatory molecules compared to unexposed cells. This suggests that moderate levels of cell phone radiation don't trigger brain inflammation in laboratory conditions.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.95 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.95 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 1950 MHz IMT‐2000 Duration: 2 h

Study Details

To examine any biological effects on the central nervous system (CNS) induced by 1950 MHz modulation signals, which are controlled by the International Mobile Telecommunication‐2000 (IMT‐2000) cellular system, we investigated the effect of RF fields on microglial cells in the brain.

We assessed functional changes in microglial cells by examining changes in immune reaction‐related ...

Results showed that the percentage of cells positive for major histocompatibility complex (MHC) clas...

These findings suggest that exposure to RF fields up to 2 W/kg does not activate microglial cells in vitro.

Cite This Study
Hirose H, Sasaki A, Ishii N, Sekijima M, Iyama T, Nojima T, Ugawa Y. (2010). 1950 MHz IMT-2000 field does not activate microglial cells in vitro. Bioelectromagnetics. 31(2):104-112, 2010.
Show BibTeX
@article{h_2010_1950_mhz_imt2000_field_2763,
  author = {Hirose H and Sasaki A and Ishii N and Sekijima M and Iyama T and Nojima T and Ugawa Y. },
  title = {1950 MHz IMT-2000 field does not activate microglial cells in vitro.},
  year = {2010},
  doi = {10.1002/bem.20532},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20532},
}
DOI: 10.1002/bem.20532

Cited By (32 papers)

Quick Questions About This Study

No, a 2010 study found that 1950 MHz IMT-2000 radiation at levels up to 2.0 W/kg for two hours did not activate microglial cells (brain immune cells) in laboratory conditions. The researchers saw no inflammatory response or increased production of inflammatory molecules.
Research shows W-CDMA signals do not trigger brain inflammation. When scientists exposed brain immune cells to W-CDMA radiation for two hours, they found no statistically significant differences in activation markers or inflammatory molecule production compared to unexposed control cells.
Microglia cells exposed to 2 W/kg of 1950 MHz radiation showed no signs of activation. The percentage of cells positive for activation markers remained similar to unexposed controls, and no remarkable differences in inflammatory molecule production were observed.
Two-hour exposure to IMT-2000 frequencies at 1950 MHz does not affect brain immune cells. Laboratory testing found no activation of microglial cells or increased production of inflammatory substances like TNF-α, IL-1β, and IL-6 at exposure levels up to 2 W/kg.
No, MHC class II markers are not affected by 1950 MHz radiation exposure. The percentage of microglial cells positive for MHC class II (the most common activation marker) remained similar between radiation-exposed cells and sham-exposed controls in laboratory testing.