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Cellular Effects

Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes.

No Effects Found

Messiha HL, Wongnate T, Chaiyen P, Jones AR, Scrutton NS · 2015

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Laboratory tests found no evidence that magnetic fields disrupt crucial cellular enzymes through the proposed radical pair mechanism.

Plain English Summary

Summary written for general audiences

Researchers investigated whether magnetic fields could affect important cellular enzymes called flavoenzymes by disrupting chemical reactions that involve unpaired electrons (radical pairs). Despite testing multiple enzyme systems under controlled laboratory conditions, they found no evidence that magnetic field exposure altered the speed or efficiency of these crucial cellular reactions. This suggests that the radical pair mechanism - a proposed biological pathway for how magnetic fields might affect living cells - may not operate in these fundamental enzymatic processes.

Study Details

we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles.

We also investigated the magnetic field sensitivity of a model system involving stepwise reduction o...

Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction ...

Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzyme-catalysed reactions are unlikely to be influenced by exposure to external magnetic fields.

Cite This Study
Messiha HL, Wongnate T, Chaiyen P, Jones AR, Scrutton NS (2015). Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes. J R Soc Interface. 2015 Feb 6;12(103). pii: 20141155. doi: 10.1098/rsif.2014.1155.
Show BibTeX
@article{hl_2015_magnetic_field_effects_as_2856,
  author = {Messiha HL and Wongnate T and Chaiyen P and Jones AR and Scrutton NS},
  title = {Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes.},
  year = {2015},
  doi = {10.1098/rsif.2014.1155},
  url = {https://royalsocietypublishing.org/doi/full/10.1098/rsif.2014.1155},
}
DOI: 10.1098/rsif.2014.1155

Cited By (31 papers)

Quick Questions About This Study

No, magnetic fields do not affect flavoenzyme reactions according to 2015 research by Messiha and colleagues. Despite testing multiple enzyme systems under controlled conditions, researchers found no evidence that magnetic field exposure altered the speed or efficiency of these crucial cellular reactions.
The radical pair mechanism is unlikely to explain magnetic field effects on flavoenzymes. Research published in 2015 found that thermally driven, flavoenzyme-catalyzed reactions showed no magnetic field sensitivity, suggesting this proposed biological pathway doesn't operate in these fundamental enzymatic processes.
Flavoenzymes are not sensitive to external magnetic field exposure based on laboratory testing. Researchers used stopped-flow measurements to analyze reaction kinetics and found no magnetic field sensitivity in any of the flavoenzyme systems they studied under experimental conditions.
Magnetic fields do not change enzyme reaction speeds in living cells according to 2015 research. Scientists tested multiple flavoenzyme systems and found no evidence that magnetic field exposure altered either the speed or efficiency of these important cellular reactions.
Thermally driven enzyme reactions don't respond to magnetic fields because the thermal energy overwhelms any potential magnetic field effects. Research on flavoenzymes concluded that these reactions are unlikely to be influenced by external magnetic field exposure under normal biological conditions.