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Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells.

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Çiğ B, Nazıroğlu M. · 2015

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Exposure to mobile phone and Wi-Fi radiation within 10 cm increased oxidative stress, apoptosis, and calcium levels in breast cancer cells, but no significant difference was found at 20 and 25 cm.

Plain English Summary

Summary written for general audiences

Researchers exposed MCF-7 breast cancer cells to 900, 1800, and 2450 MHz electromagnetic radiation at distances from 0 to 25 cm for one hour. At distances of 0, 1, and 5 cm, exposed cells showed higher reactive oxygen species, calcium concentrations, apoptosis, and caspase activity compared to controls, while cell viability increased with distance. No statistically significant differences were observed between control cells and those exposed at 20 or 25 cm.

Why This Matters

The study aimed to investigate how distance from mobile phone and Wi-Fi sources affects calcium signaling, oxidative stress, cell viability, and apoptosis in breast cancer cells. The authors reported that electromagnetic radiation within 10 cm induced excessive oxidative responses and apoptosis through TRPV1-mediated calcium accumulation. They suggested that keeping cell phones and Wi-Fi sources farther than 10 cm may protect against oxidative stress, apoptosis, and calcium overload.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900, 1800 and 2450 MHz Duration: 1 hour

Study Details

We aimed to investigate the effects of distance from sources on calcium signaling, cytosolic ROS production, cell viability, apoptosis, plus caspase-3 and -9 values induced by mobile phones and Wi-Fi in breast cancer cells MCF-7 human breast cancer cell lines were divided into A, B, C and D groups as control, 900, 1800 and 2450 MHz groups, respectively.

Cells in Group A were used as control and were kept in cell culture conditions without EMR exposure....

The cytosolic ROS production, Ca2+ concentrations, apoptosis, caspase-3 and caspase-9 values were hi...

Cite This Study
Çiğ B, Nazıroğlu M. (2015). Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells. Biochim Biophys Acta. 2015 Feb 19. pii: S0005-2736(15)00053-X. doi: 10.1016/j.bbamem.2015.02.013.
Show BibTeX
@article{b_2015_investigation_of_the_effects_1986,
  author = {Çiğ B and Nazıroğlu M.},
  title = {Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/25703814/},
}
PubMed: 25703814

Cited By (71 papers)

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Quick Questions About This Study

The study used MCF-7 human breast cancer cell lines.
The cells were exposed to 900 MHz, 1800 MHz, and 2450 MHz electromagnetic radiation.
Exposure distances were 0, 1, 5, 10, 20, and 25 cm for one hour before CAP stimulation.
At 0, 1, and 5 cm, exposed cells had higher reactive oxygen species, calcium levels, apoptosis, and caspase activity than controls.
No statistically significant differences were found between control cells and those exposed at 20 or 25 cm.