Indirect effects of interference of two emerging environmental contaminants on cell health: Radiofrequency radiation and gold nanoparticles
Authors not listed · 2023
RFR increased metabolic death in cells treated with gold nanoparticles and reduced colony formation in bystander and RFR-exposed cells whether or not gold nanoparticles were present.
Plain English Summary
Researchers exposed Chinese hamster ovary cells to a non-toxic dose of 15-nm gold nanoparticles for 48 hours and then to 900 MHz GSM radiofrequency radiation for 24 hours. The conditioned medium from these cells was transferred to new bystander cells, and cell death, DNA breaks, oxidative stress, and COX-2 expression were measured. RFR increased metabolic death in GNP-treated cells, while colony formation was reduced in bystander cells and RFR-exposed cells regardless of GNP presence. ROS levels were significantly lower in GNP-treated cells, but RFR-induced DNA breaks and micronuclei frequencies were not significantly affected by GNP.
Why This Matters
The authors state that this is the first demonstration that RFR can induce indirect effects in the presence of gold nanoparticles. They also report that the molecular mediators of these indirect effects differ from those observed without gold nanoparticles. Additionally, the study concludes that COX-2 is not involved in the bystander effect induced by 900 MHz RFR.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{indirect_effects_of_interference_of_two_emerging_environmental_contaminants_on_cell_health_radiofrequency_radiation_and_gold_nanoparticles_ce2436,
author = {Unknown},
title = {Indirect effects of interference of two emerging environmental contaminants on cell health: Radiofrequency radiation and gold nanoparticles},
year = {2023},
doi = {10.1016/j.chemosphere.2023.140942},
}