Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts
Authors not listed · 2002
Intermittent exposure to 50 Hz ELF-EMF significantly increased DNA strand breaks, mainly DSBs, in human diploid fibroblasts.
Plain English Summary
Human diploid fibroblasts were exposed to continuous or intermittent ELF-EMF at 50 Hz, sinusoidal, for 24 hours at 1000 microT. The alkaline and neutral comet assays were used to evaluate DNA single-strand and double-strand breaks. Intermittent fields reproducibly resulted in a significant increase of DNA strand break levels, mainly DSBs, compared to non-exposed controls. The highest DNA strand break levels occurred with 5 minutes field-on and 10 minutes field-off intermittence.
Why This Matters
The researchers also found individual differences in response to ELF-EMF and an evident exposure-response relationship between magnetic flux density and DNA migration in the comet assay. The data strongly indicate a genotoxic potential of intermittent EMF.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{induction_of_dna_strand_breaks_by_intermittent_exposure_to_extremely_low_frequency_electromagnetic_fields_in_human_diploid_fibroblasts_ce1509,
author = {Unknown},
title = {Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts},
year = {2002},
doi = {10.1016/S1383-5718(02)00109-2},
}