Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields
Bioeffects Seen
Authors not listed · 2005
Exposure to 50Hz electromagnetic fields shifted tamoxifen dose-response curves to higher concentrations in MCF-7 breast cancer cells, with maximal effect at 1.2muT.
Plain English Summary
Summary written for general audiences
Researchers exposed two clones of MCF-7 breast cancer cells to 50Hz electromagnetic fields and calculated IC(50) values from tamoxifen dose-response curves. The dose-response curves shifted to higher tamoxifen concentrations in an intensity-dependent manner, with a maximal response at 1.2muT. The authors hypothesized that electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.
Exposure Information
Specific exposure levels were not quantified in this study.
Cite This Study
Unknown (2005). Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields.
Show BibTeX
@article{induction_of_tamoxifen_resistance_in_breast_cancer_cells_by_elf_electromagnetic_fields_ce1463,
author = {Unknown},
title = {Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields},
year = {2005},
doi = {10.1016/J.BBRC.2005.08.243},
}Quick Questions About This Study
Two different clones of the MCF-7 breast cancer cell line were used.
The cells were exposed to highly homogeneous 50Hz electromagnetic fields at various intensities, with a maximal response observed at 1.2muT.
The curves shifted to higher tamoxifen concentrations in an intensity-dependent manner, with a maximal response at 1.2muT.
They hypothesized that electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.
IC(50) values were calculated from dose-response curves of tamoxifen at various field intensities.