Investigation of oxidative damage, antioxidant balance, DNA repair genes, and apoptosis due to radiofrequency-induced adaptive response in mice
Authors not listed · 2022
Mice exposed to 900 MHz GSM RF showed increased ROS and DNA-repair gene expression and reduced apoptosis.
Plain English Summary
The study used 24 adult male Swiss-Albino mice divided into Four groups of 6. The radiofrequency and adaptive response groups were exposed to a 900 MHz GSM signal at 0.339 W/kg for 4 h/day over 7 days. After the final exposure, bleomycin was injected intraperitoneally at 37.5 mg/kg and the mice were sacrificed 30 minutes later. Oxidative damage and antioxidant mechanisms were examined in blood, DNA-repair gene expression was measured in liver, and apoptosis was assessed in liver using the TUNEL method. The adaptive response group showed increased ROS and p53 and OGG-1 expression, decreased SOD, CAT and TAC levels, and reduced apoptosis.
Why This Matters
The authors suggest that the rise in ROS may have played an important role in triggering the adaptive response and producing the required minimum stress level. Expression of PARP-1 and GPx-1 did not change significantly after RF exposure. They concluded that RF radiation may create a protective reaction against bleomycin and that minimal oxidative stress from RF exposure leads to an adaptive response in DNA-repair genes and enzymes, enabling cell survival.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{investigation_of_oxidative_damage_antioxidant_balance_dna_repair_genes_and_apoptosis_due_to_radiofrequency_induced_adaptive_response_in_mice_ce2466,
author = {Unknown},
title = {Investigation of oxidative damage, antioxidant balance, DNA repair genes, and apoptosis due to radiofrequency-induced adaptive response in mice},
year = {2022},
doi = {10.1080/15368378.2022.2117187},
}