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DNA & Genetic Damage

Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells.

No Effects Found

Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS. · 2015

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Exposure to 60 Hz ELF-MF alone or combined with ionizing radiation or hydrogen peroxide did not increase G2/M arrest or aneuploidy in non-tumorigenic human lung epithelial L132 cells.

Plain English Summary

Summary written for general audiences

Researchers assessed whether combined exposure to 60 Hz ELF-MF at 1 mT or 2 mT with ionizing radiation or hydrogen peroxide causes genomic instability in non-tumorigenic human lung epithelial L132 cells. They examined the percentages of G2/M-arrested cells and aneuploid cells after exposures. Exposure to 0.5 Gy ionizing radiation or 0.05 mM hydrogen peroxide for 9 hours increased aneuploidy but did not cause apoptotic cell death. ELF-MF alone did not affect the percentages of G2/M-arrested cells, aneuploid cells, or subG1 phase populations. Combining ELF-MF with ionizing radiation or hydrogen peroxide did not further increase G2/M arrest or aneuploidy.

Exposure Details

Magnetic Field
1 or 2 mT
Source/Device
60 Hz
Exposure Duration
9h

Exposure Context

This study used 1 or 2 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 or 2 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 5 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 60 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells.

To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined.

Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however,...

These results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when administered in combination with different stressors.

Cite This Study
Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS. (2015). Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells. Korean J Physiol Pharmacol. 19(2):119-124, 2015.
Show BibTeX
@article{h_2015_effects_on_g2m_phase_2849,
  author = {Jin H and Yoon HE and Lee JS and Kim JK and Myung SH and Lee YS.},
  title = {Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/25729273/},
}
PubMed: 25729273

Cited By (9 papers)

Quick Questions About This Study

The study aimed to assess whether combined exposure to 60 Hz ELF-MF and stressors like ionizing radiation or hydrogen peroxide causes genomic instability in non-tumorigenic human lung epithelial L132 cells.
ELF-MF alone did not affect the percentages of G2/M-arrested cells, aneuploid cells, or subG1 phase populations.
Combining ELF-MF with ionizing radiation or hydrogen peroxide did not further increase G2/M arrest or aneuploidy.
The results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when administered in combination with different stressors.